Hofmeister phenomena: an update on ion specificity in biology

P Lo Nostro, BW Ninham - Chemical reviews, 2012 - ACS Publications
Specific ion effects occur everywhere. They occur in bulk solutions and at interfaces
(air/water, oil/water, solid/water, macromolecule/water, etc.). They are even found in …

[HTML][HTML] Protein phase separation and its role in tumorigenesis

S Jiang, JB Fagman, C Chen, S Alberti, B Liu - Elife, 2020 - elifesciences.org
Cancer is a disease characterized by uncontrolled cell proliferation, but the precise
pathological mechanisms underlying tumorigenesis often remain to be elucidated. In recent …

The self-assembly, aggregation and phase transitions of food protein systems in one, two and three dimensions

R Mezzenga, P Fischer - Reports on Progress in Physics, 2013 - iopscience.iop.org
The aggregation of proteins is of fundamental relevance in a number of daily phenomena,
as important and diverse as blood coagulation, medical diseases, or cooking an egg in the …

Molecular nucleation mechanisms and control strategies for crystal polymorph selection

AES Van Driessche, N Van Gerven, PHH Bomans… - Nature, 2018 - nature.com
The formation of condensed (compacted) protein phases is associated with a wide range of
human disorders, such as eye cataracts, amyotrophic lateral sclerosis, sickle cell anaemia …

Binary-liquid phase separation of lens protein solutions.

ML Broide, CR Berland, J Pande… - Proceedings of the …, 1991 - National Acad Sciences
We have determined the coexistence curves (plots of phase-separation temperature T
versus protein concentration C) for aqueous solutions of purified calf lens proteins. The …

Binary liquid phase separation and critical phenomena in a protein/water solution.

JA Thomson, P Schurtenberger… - Proceedings of the …, 1987 - National Acad Sciences
We have investigated the phase diagram of aqueous solutions of the bovine lens protein
gamma II-crystallin. For temperatures T less than Tc= 278.5 K, we find that these solutions …

Fundamental Aspects of Phase-Separated Biomolecular Condensates

HX Zhou, D Kota, S Qin, R Prasad - Chemical Reviews, 2024 - ACS Publications
Biomolecular condensates, formed through phase separation, are upending our
understanding in much of molecular, cell, and developmental biology. There is an urgent …

Using phase transitions to investigate the effect of salts on protein interactions

ML Broide, TM Tominc, MD Saxowsky - Physical Review E, 1996 - APS
We have investigated liquid-liquid and solid-liquid phase separation of aqueous solutions of
lysozyme. We have determined experimentally how the phase transition temperatures …

[HTML][HTML] Potential and limits of a colloid approach to protein solutions

A Stradner, P Schurtenberger - Soft Matter, 2020 - pubs.rsc.org
Looking at globular proteins with the eyes of a colloid scientist has a long tradition, in fact a
significant part of the early colloid literature was focused on protein solutions. However, it …

Multivalent ions and biomolecules: Attempting a comprehensive perspective

O Matsarskaia, F Roosen‐Runge… - ChemPhysChem, 2020 - Wiley Online Library
Ions are ubiquitous in nature. They play a key role for many biological processes on the
molecular scale, from molecular interactions, to mechanical properties, to folding, to self …