In this Review, I present evidence supporting a multifactorial causation of childhood acute
lymphoblastic leukaemia (ALL), a major subtype of paediatric cancer. ALL evolves in two …

Purpose To review the impact of collaborative studies on advances in the biology and
treatment of acute lymphoblastic leukemia (ALL) in children and adolescents. Methods A …

Genome-wide association studies (GWAS) provide an agnostic approach for investigating
the genetic basis of complex diseases. In oncology, GWAS of nearly all common …

Although much work has focused on the elucidation of somatic alterations that drive the
development of acute leukaemias and other haematopoietic diseases, it has become …

Purpose Somatic deletions that affect the lymphoid transcription factor–coding gene IKZF1
have previously been reported as independently associated with a poor prognosis in …

Acute lymphoblastic leukemia (ALL) is the commonest childhood tumor and remains a
leading cause of cancer death in the young. In the last decade, microarray and sequencing …

Acute lymphoblastic leukaemia (ALL) is the commonest childhood cancer and an important
cause of morbidity from haematological malignancies in adults. In the past several years, we …

The causes of childhood cancer have been systematically studied for several decades, but
apart from high-dose radiation and prior chemotherapy there are few or no strong external …

Background Hereditary predisposition is rarely suspected for childhood acute lymphoblastic
leukaemia (ALL). Recent reports of germline ETV6 variations associated with substantial …

Inherited noncoding genetic variants confer significant disease susceptibility to childhood
acute lymphoblastic leukemia (ALL) but the molecular processes linking germline …