[HTML][HTML] Therapeutic advances of miRNAs: A preclinical and clinical update

C Chakraborty, AR Sharma, G Sharma… - Journal of advanced …, 2021 - Elsevier
Background miRNAs, a class of small endogenous RNAs, are one of the essential
biopharmaceuticals which are in commercial spans as next-generation medicine in recent …

[HTML][HTML] MicroRNAs as therapeutic targets in cardiovascular disease

B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …

[HTML][HTML] Current advances in RNA therapeutics for human diseases

H Zogg, R Singh, S Ro - International journal of molecular sciences, 2022 - mdpi.com
Following the discovery of nucleic acids by Friedrich Miescher in 1868, DNA and RNA were
recognized as the genetic code containing the necessary information for proper cell …

Therapeutic strategies for enhancing angiogenesis in wound healing

AP Veith, K Henderson, A Spencer, AD Sligar… - Advanced drug delivery …, 2019 - Elsevier
The enhancement of wound healing has been a goal of medical practitioners for thousands
of years. The development of chronic, non-healing wounds is a persistent medical problem …

Nitric oxide signalling in cardiovascular health and disease

C Farah, LYM Michel, JL Balligand - Nature Reviews Cardiology, 2018 - nature.com
Nitric oxide (NO) signalling has pleiotropic roles in biology and a crucial function in
cardiovascular homeostasis. Tremendous knowledge has been accumulated on the …

Non-coding RNAs in development and disease: background, mechanisms, and therapeutic approaches

J Beermann, MT Piccoli, J Viereck… - Physiological …, 2016 - journals.physiology.org
Advances in RNA-sequencing techniques have led to the discovery of thousands of non-
coding transcripts with unknown function. There are several types of non-coding linear …

[HTML][HTML] Non-coding RNAs in human health and disease: potential function as biomarkers and therapeutic targets

T Loganathan, GP Doss C - Functional & integrative genomics, 2023 - Springer
Human diseases have been a critical threat from the beginning of human history. Knowing
the origin, course of action and treatment of any disease state is essential. A microscopic …

New directions in therapeutic angiogenesis and arteriogenesis in peripheral arterial disease

BH Annex, JP Cooke - Circulation research, 2021 - Am Heart Assoc
The prevalence of peripheral arterial disease (PAD) in the United States exceeds 10 million
people, and PAD is a significant cause of morbidity and mortality across the globe. PAD is …

Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

Z Ungvari, S Tarantini, T Kiss, JD Wren… - Nature Reviews …, 2018 - nature.com
Ageing is the main risk factor for the development of cardiovascular diseases. A central
mechanism by which ageing promotes vascular pathologies is compromising endothelial …

MicroRNA regulation of atherosclerosis

MW Feinberg, KJ Moore - Circulation research, 2016 - Am Heart Assoc
Atherosclerosis and its attendant clinical complications, such as myocardial infarction,
stroke, and peripheral artery disease, are the leading cause of morbidity and mortality in …