Telomerase is a ribonucleoprotein (RNP) responsible for the maintenance of chromosomal
integrity by stabilizing telomere length. Telomerase is a widely expressed hallmark …

The anatomical architecture of the human liver and the diversity of its immune components
endow the liver with its physiological function of immune competence. Adaptive immunity is …

Recurrent somatic mutations in the promoter region of telomerase reverse transcriptase
(TERT) gene and in the exon 3 of CTNNB1 gene have been recognized as common events …

PTEN is the second most frequently mutated tumor suppresser gene in cancers after p53.
Genetic and epigenetic alterations in the PTEN gene and its regulatory regions have been …

Primary hepatocellular carcinoma (HCC) mainly develops in subjects chronically infected
with hepatitis B (HBV) and C (HCV) viruses through a multistep process characterized by the …

Telomeres are linear guanine-rich DNA structures at the ends of chromosomes. The length
of telomeric DNA is actively regulated by a number of mechanisms in highly proliferative …

Hepatocellular carcinoma (HCC) represents the primary carcinoma of the liver and the fourth
leading cause of cancer-related deaths. The World Health Organization estimates an …

Abstract Background & Aim Telomere length and telomerase have been linked with cirrhosis
and hepatocellular carcinoma. However, the impact of telomere length on nonalcoholic fatty …

Although telomerase has low activity in somatic quiescent cells, it plays an significant roles
in regenerative cells such as endothelial cells, hepatocytes, epithelial cells, and hemocytes …

Nonalcoholic fatty liver disease (NAFLD) is a group of liver disorders encompassing simple
hepatic steatosis and its more aggressive forms of nonalcoholic steatohepatitis and …