The environment, diet, microbiota and body's metabolism shape complex biological
processes in health and disease. However, our understanding of the molecular pathways …

Postoperative cognitive dysfunction (POCD), as one of the common postoperative
complications, mainly occurs after surgery and anesthesia, especially in the elderly. It refers …

As tissue macrophages of the central nervous system (CNS), microglia constitute the pivotal
immune cells of this organ. Microglial features are strongly dependent on environmental …

It was recently revealed that gut microbiota promote amyloid-beta (Aβ) burden in mouse
models of Alzheimer's disease (AD). However, the underlying mechanisms when using …

Background Increasing evidence links the gut microbiota (GM) to Alzheimer's disease (AD)
but the mechanisms through which gut bacteria influence the brain are still unclear. This …

The innate immune system in the central nervous system (CNS) is mainly represented by
specialized tissue‐resident macrophages, called microglia. In the past years, various …

Background Surgery-induced neuroinflammation plays an important role in postoperative
cognitive dysfunction (POCD). Gut microbiota is a key regulator of neurological …

The analysis of human microbiome is an exciting and rapidly expanding field of research. In
the past decade, the biological relevance of the microbiome for human health has become …

Alzheimer's disease (AD), a progressive neurodegenerative disorder, lacks preclinical
diagnostic biomarkers and therapeutic drugs. Thus, earlier intervention in AD is a top …

After spinal cord injury (SCI), intestinal dysfunction has a serious impact on physical and
mental health, quality of life, and social participation. Recent data from rodent and human …