Therapeutic Potential of 5-HT6 Receptor Agonists: Miniperspective
D Karila, T Freret, V Bouet, M Boulouard… - Journal of medicinal …, 2015 - ACS Publications
Given its predominant expression in the central nervous system (CNS), 5-hydroxytryptamine
(5-HT: serotonin) subtype 6 receptor (5-HT6R) has been considered as a valuable target for …
(5-HT: serotonin) subtype 6 receptor (5-HT6R) has been considered as a valuable target for …
Direct interrogation of context-dependent GPCR activity with a universal biosensor platform
G protein-coupled receptors (GPCRs) are the largest family of druggable proteins encoded
in the human genome, but progress in understanding and targeting them is hindered by the …
in the human genome, but progress in understanding and targeting them is hindered by the …
Structural predictions of the SNX-RGS proteins suggest they belong to a new class of lipid transfer proteins
Recent advances in protein structure prediction using machine learning such as AlphaFold2
and RosettaFold presage a revolution in structural biology. Genome-wide predictions of …
and RosettaFold presage a revolution in structural biology. Genome-wide predictions of …
SNX14 mutations affect endoplasmic reticulum-associated neutral lipid metabolism in autosomal recessive spinocerebellar ataxia 20
Mutations in SNX14 cause the autosomal recessive cerebellar ataxia 20 (SCAR20).
Mutations generally result in loss of protein although several coding region deletions have …
Mutations generally result in loss of protein although several coding region deletions have …
Serotonin, neural markers, and memory
A Meneses - Frontiers in pharmacology, 2015 - frontiersin.org
Diverse neuropsychiatric disorders present dysfunctional memory and no effective treatment
exits for them; likely as result of the absence of neural markers associated to memory …
exits for them; likely as result of the absence of neural markers associated to memory …
The retromer, sorting nexins and the plant endomembrane protein trafficking
N Heucken, R Ivanov - Journal of cell science, 2018 - journals.biologists.com
Protein sorting in the endomembrane system is responsible for the coordination of cellular
functions. Plant intracellular trafficking has its own unique features, which include specific …
functions. Plant intracellular trafficking has its own unique features, which include specific …
The 5-HT6 receptor interactome: New insight in receptor signaling and its impact on brain physiology and pathologies
Abstract The serotonin (5-HT) 6 receptor is a Gs-coupled receptor exclusively expressed in
the central nervous system. Highest receptor densities are found in brain regions implicated …
the central nervous system. Highest receptor densities are found in brain regions implicated …
A compendium of Androgen Receptor Variant 7 target genes and their role in Castration Resistant Prostate Cancer
KJ Miller, I Henry, Z Maylin, C Smith… - Frontiers in …, 2023 - frontiersin.org
Persistent androgen receptor (AR) signalling is the main driver of prostate cancer (PCa).
Truncated isoforms of the AR called androgen receptor variants (AR-Vs) lacking the ligand …
Truncated isoforms of the AR called androgen receptor variants (AR-Vs) lacking the ligand …
The emerging role of sorting nexins in cardiovascular diseases
J Yang, VAM Villar, S Rozyyev, PA Jose… - Clinical …, 2019 - portlandpress.com
The sorting nexin (SNX) family consists of a diverse group of cytoplasmic-and membrane-
associated phosphoinositide-binding proteins that play pivotal roles in the regulation of …
associated phosphoinositide-binding proteins that play pivotal roles in the regulation of …
Sorting out sorting nexins functions in the nervous system in health and disease
Endocytosis is a fundamental process that controls protein/lipid composition of the plasma
membrane, thereby shaping cellular metabolism, sensing, adhesion, signaling, and nutrient …
membrane, thereby shaping cellular metabolism, sensing, adhesion, signaling, and nutrient …