Enzymes are essential biological elements that play vital roles in many key cellular events
and physiological processes. The dysregulation of enzyme activity broadly occurs in a large …

Efforts to define serological correlates of protection against COVID-19 have been hampered
by the lack of a simple, scalable, standardised assay for SARS-CoV-2 infection and antibody …

Dengue and West Nile virus are rapidly spreading global pathogens for which no specific
therapeutic treatments are available. One of the promising targets for drug discovery against …

Positive-strand RNA viruses have been the etiological agents in several major disease
outbreaks over the last few decades. Examples of this include flaviviruses, such as dengue …

Transmembrane drug transport in hepatocytes is one of the major determinants of drug
pharmacokinetics. In the present study, ABC transporters (P-gp, MRP1, MRP2, MRP3 …

Infection by flaviviruses leads to dramatic remodeling of the endoplasmic reticulum (ER).
Viral replication occurs within virus-induced vesicular invaginations in the ER membrane. A …

Conventional plaque assays rely on the use of overlays to restrict viral infection allowing the
formation of distinct foci that grow in time as the replication cycle continues leading to …

Zika virus (ZIKV) is a mosquito-borne flavivirus in which human infection became relevant
during recent outbreaks in Latin America due to its unrecognized association with fetal …

The cytopathic effect comprises the set of cellular alterations produced by a viral infection. It
is of great relevance since it constitutes a direct marker of infection. Likewise, these …

Incidence of dengue virus (DENV) and Zika virus (ZIKV), two mosquito-borne flaviviruses, is
increasing in large parts of the world. Vaccination and medication for these diseases are …