Importance Sickle cell disease (SCD) is a monogenic disorder, yet clinical outcomes are
influenced by additional genetic factors. Despite decades of research, the genetics of SCD …

Sickle cell disease (SCD) is one of the most common hereditary hemoglobinopathies
worldwide, affecting almost 400,000 newborns globally each year. It is characterized by …

Background: Ischemia reperfusion injury (I/RI) is a common complication of cardiovascular
diseases. Resolution of detrimental I/RI-generated prothrombotic and proinflammatory …

Neutrophils play a crucial role in the intertwined processes of thrombosis and inflammation.
An altered neutrophil phenotype may contribute to inadequate resolution, which is known to …

Introduction Sex-based clinical outcome differences in sickle cell disease (SCD) remain
largely unknown despite evidence that female sex is associated with an increased lifespan …

Memory T cells are conventionally subdivided into T central memory (TCM) and T effector
memory (TEM) cells. However, a new subset of memory T cells named T memory stem cell …

While neutrophils are the main effectors of protective innate immune responses, they are
also key players in inflammatory pathologies. Sickle cell disease (SCD) is a genetic blood …

Adult patients with sickle cell disease (SCD) are highly susceptible to stem cell transplant
complications, including drug toxicity, graft versus host disease (GVHD), and graft rejection …

As cancer mortality is high in most regions of the world, early screening of cancer has
become increasingly important. Minimally invasive screening programs that use peripheral …

Sickle cell disease (SCD) is a well-studied monogenetic disease with an established chronic
inflammatory component. The paradigm shift towards inflammation has made the …