Extracellular vesicles as communicators of senescence in musculoskeletal aging
MC Alfonzo, A Al Saedi, S Fulzele… - Journal of Bone and …, 2022 - academic.oup.com
Extracellular vesicles (EVs), including exosomes and microvesicles, are released by
numerous cell types. EVs are now acknowledged as playing a critical role in cell–cell …
numerous cell types. EVs are now acknowledged as playing a critical role in cell–cell …
[HTML][HTML] Enhancement of the therapeutic efficacy of mesenchymal stem cell-derived exosomes in osteoarthritis
Z Zhang, S Zhao, Z Sun, C Zhai, J Xia, C Wen… - Cellular & Molecular …, 2023 - Springer
Osteoarthritis (OA), a common joint disorder with articular cartilage degradation as the main
pathological change, is the major source of pain and disability worldwide. Despite current …
pathological change, is the major source of pain and disability worldwide. Despite current …
miR-125a-5p-abundant exosomes derived from mesenchymal stem cells suppress chondrocyte degeneration via targeting E2F2 in traumatic osteoarthritis
Q Xia, Q Wang, F Lin, J Wang - Bioengineered, 2021 - Taylor & Francis
ABSTRACT miRNAs are broad participants in vertebrate biological processes, and they are
also the major players in pathological processes. miR-125a-5p was recently found a …
also the major players in pathological processes. miR-125a-5p was recently found a …
[HTML][HTML] Exosomes: Small vesicles with important roles in the development, metastasis and treatment of breast cancer
L Meng, K Song, S Li, Y Kang - Membranes, 2022 - mdpi.com
Breast cancer (BC) has now overtaken lung cancer as the most common cancer, while no
biopredictive marker isolated from biological fluids has yet emerged clinically. After …
biopredictive marker isolated from biological fluids has yet emerged clinically. After …
[HTML][HTML] Extracellular Vesicle-Mediated miR-150-3p Delivery in Joint Homeostasis: A Potential Treatment for Osteoarthritis?
H Wang, J Shu, C Zhang, Y Wang, R Shi, F Yang… - Cells, 2022 - mdpi.com
Background: The disruption of joint homeostasis is a critical event during the process of joint
injury in osteoarthritis (OA). As regulatory molecules, microRNAs (miRNAs) can be released …
injury in osteoarthritis (OA). As regulatory molecules, microRNAs (miRNAs) can be released …
miR-26a deficiency is associated with bone loss and reduced muscle strength but does not affect severity of cartilage damage in osteoarthritis
Osteoarthritis (OA) is the most common age-related joint disease. However, the role of many
microRNAs (miRNA) in skeletal development and OA pathogenesis has not been sufficiently …
microRNAs (miRNA) in skeletal development and OA pathogenesis has not been sufficiently …
[HTML][HTML] miR-23a/b clusters are not essential for the pathogenesis of osteoarthritis in mouse aging and post-traumatic models
Osteoarthritis (OA), the most prevalent aging-related joint disease, is characterized by
insufficient extracellular matrix synthesis and articular cartilage degradation and is caused …
insufficient extracellular matrix synthesis and articular cartilage degradation and is caused …
[HTML][HTML] Osteoarthritis and microRNAs: Do They Provide Novel Insights into the Pathophysiology of This Degenerative Disorder?
SI Stanciugelu, C Homorogan, C Selaru, JM Patrascu… - Life, 2022 - mdpi.com
Osteoarthritis (OA) is one of the most prevalent degenerative joint diseases in older adults
and a leading cause of disability. Recent research studies have evidenced the importance of …
and a leading cause of disability. Recent research studies have evidenced the importance of …
The role of exosomal non‐coding RNAs in aging‐related diseases
Aging is a biological process caused by the accumulation of senescent cells with a
permanent proliferative arrest. To the influence of aging on human life expectancy, there is …
permanent proliferative arrest. To the influence of aging on human life expectancy, there is …
[HTML][HTML] Plasma and synovial fluid extracellular vesicles display altered microRNA profiles in horses with naturally occurring post-traumatic osteoarthritis: an …
SS Connard, AM Gaesser, EJ Clarke… - Journal of the …, 2024 - Am Vet Med Assoc
Representative images from radiocarpal, middle carpal, and metacarpophalangeal joints
classified as advanced post-traumatic osteoarthritis (PTOA) based on the modified …
classified as advanced post-traumatic osteoarthritis (PTOA) based on the modified …