▪ Abstract Alternative pre-mRNA splicing is a central mode of genetic regulation in higher
eukaryotes. Variability in splicing patterns is a major source of protein diversity from the …

Formation of mRNA 3′ ends in eukaryotes requires the interaction of transacting factors
with cis-acting signal elements on the RNA precursor by two distinct mechanisms, one for …

Regulation, recognition and cell signaling involve the coordinated actions of many players.
To achieve this coordination, each participant must have a valid identification (ID) that is …

MicroRNAs (miRNAs) are implicated in both tissue differentiation and maintenance of tissue
identity. In most cases, however, the mechanisms underlying their regulation are not known …

Alternative splicing of mRNA precursors is a versatile mechanism of gene expression
regulation that accounts for a considerable proportion of proteomic complexity in higher …

Alternative splicing is an important mechanism for controlling gene expression. It allows
large proteomic complexity from a limited number of genes. An interplay of cis-acting …

Proteins of the heterogeneous nuclear ribonucleoparticles (hnRNP) family form a structurally
diverse group of RNA binding proteins implicated in various functions in metazoans. Here …

Polypyrimdine tract binding protein (PTB) is a regulator of alternative splicing, mRNA 3′
end formation, mRNA stability and localization, and IRES-mediated translation. Transient …

PTB (polypyrimidine-tract-binding protein) is a ubiquitous RNA-binding protein. It was
originally identified as a protein with a role in splicing but it is now known to function in a …

Splicing of the c-src N1 exon in neuronal cells depends in part on an intronic cluster of RNA
regulatory elements called the downstream control sequence (DCS). Using site-specific …