The neurohypophysial peptide oxytocin (OT) and OT-like hormones facilitate reproduction in
all vertebrates at several levels. The major site of OT gene expression is the magnocellular …

Among membrane‐bound receptors, the G protein‐coupled receptors (GPCRs) are certainly
the most diverse. They have been very successful during evolution, being capable of …

The κ-opioid receptor (KOR) has emerged as an attractive drug target for pain management
without addiction, and biased signaling through particular pathways of KOR may be key to …

Adiponectin is an anti-diabetic adipokine. Its receptors possess a seven-transmembrane
topology with the amino terminus located intracellularly, which is the opposite of G-protein …

Abstract Corrigendum (2004) Adiponectin (also known as 30-kDa adipocyte complement-
related protein; Acrp30),,, is a hormone secreted by adipocytes that acts as an …

Many orphan G protein-coupled receptors (GPCRs) remain understudied because their
endogenous ligands are unknown. Here, we show that a group of class A/rhodopsin-like …

G protein-coupled, seven-transmembrane segment receptors (GPCRs or 7TM receptors),
with more than 1000 different members, comprise the largest superfamily of proteins in the …

G-protein-coupled receptors (GPCRs) are remarkably versatile signaling molecules.
Members of this large family of membrane proteins respond to structurally diverse ligands …

The activation of the complement cascade, a cornerstone of the innate immune response,
produces a number of small (74–77 amino acid) fragments, originally termed …

The movements of transmembrane segments (TMs) 3 and 6 at the cytoplasmic side of the
membrane play an important role in the activation of G-protein-coupled receptors. Here we …