Clinical trials targeting secondary damage after traumatic spinal cord injury

ZZ Khaing, JY Chen, G Safarians, S Ezubeik… - International journal of …, 2023 - mdpi.com
Spinal cord injury (SCI) often causes loss of sensory and motor function resulting in a
significant reduction in quality of life for patients. Currently, no therapies are available that …

Therapeutic hypothermia and targeted temperature management in traumatic brain injury: clinical challenges for successful translation

WD Dietrich, HM Bramlett - Brain research, 2016 - Elsevier
The use of therapeutic hypothermia (TH) and targeted temperature management (TTM) for
severe traumatic brain injury (TBI) has been tested in a variety of preclinical and clinical …

Breviscapine alleviates cognitive impairments induced by transient cerebral ischemia/reperfusion through its anti-inflammatory and anti-oxidant properties in a rat …

Y Li, S Li, D Li - ACS Chemical Neuroscience, 2020 - ACS Publications
Cerebral ischemia/reperfusion (I/R)-induced injury is a common phenomenon of stroke, and
the effective treatment for I/R-induced brain tissue damage is limited. Breviscapine has been …

Therapeutic hypothermia and targeted temperature management for traumatic brain injury: experimental and clinical experience

WD Dietrich, HM Bramlett - Brain circulation, 2017 - journals.lww.com
Traumatic brain injury (TBI) is a worldwide medical problem, and currently, there are few
therapeutic interventions that can protect the brain and improve functional outcomes in …

Targeted temperature management in traumatic brain injury

S Yokobori, H Yokota - Journal of intensive care, 2016 - Springer
Traumatic brain injury (TBI) is recognized as the significant cause of mortality and morbidity
in the world. To reduce unfavorable outcome in TBI patients, many researches have made …

N6-methyladenosine RNA is modified in the rat hippocampus following traumatic brain injury with hypothermia treatment

J Cheng, L Lin, J Yu, X Zhu, H Ma, Y Zhao - Frontiers in Neuroscience, 2023 - frontiersin.org
Recent studies have suggested a role for N6-methyladenosine (m6A) modification in
neurological diseases. Hypothermia, a commonly used treatment for traumatic brain injury …

[HTML][HTML] A cool approach to reducing electrode-induced trauma: localized therapeutic hypothermia conserves residual hearing in cochlear implantation

I Tamames, C King, E Bas, WD Dietrich, F Telischi… - Hearing research, 2016 - Elsevier
Objective The trauma caused during cochlear implant insertion can lead to cell death and a
loss of residual hair cells in the cochlea. Various therapeutic approaches have been studied …

Preconditioning for traumatic brain injury

S Yokobori, AT Mazzeo, K Hosein, S Gajavelli… - Translational stroke …, 2013 - Springer
Traumatic brain injury (TBI) treatment is now focused on the prevention of primary injury and
reduction of secondary injury. However, no single effective treatment is available as yet for …

Subdural hematoma decompression model: a model of traumatic brain injury with ischemic-reperfusional pathophysiology: a review of the literature

S Yokobori, R Nakae, H Yokota, MS Spurlock… - Behavioural brain …, 2018 - Elsevier
The prognosis for patients with traumatic brain injury (TBI) with subdural hematoma (SDH)
remains poor. In accordance with an increasing elderly population, the incidence of geriatric …

Delivery-mediated exosomal therapeutics in ischemia–reperfusion injury: advances, mechanisms, and future directions

S Ding, YJ Kim, KY Huang, D Um, Y Jung, H Kong - Nano Convergence, 2024 - Springer
Ischemia-reperfusion injury (IRI) poses significant challenges across various organ systems,
including the heart, brain, and kidneys. Exosomes have shown great potentials and …