This review takes an inclusive approach to microvascular dysfunction in diabetes mellitus
and cardiometabolic disease. In virtually every organ, dynamic interactions between the …

Both type 1 and type 2 diabetes adversely affect the microvasculature in multiple organs.
Our understanding of the genesis of this injury and of potential interventions to prevent, limit …

Endothelial dysfunction contributes to cardiovascular diseases, including hypertension,
atherosclerosis, and coronary artery disease, which are also characterized by insulin …

Insulin has important vascular actions to stimulate production of nitric oxide from
endothelium. This leads to capillary recruitment, vasodilation, increased blood flow, and …

In obese patients with type 2 diabetes, insulin delivery to and insulin-dependent glucose
uptake by skeletal muscle are delayed and impaired. The mechanisms underlying the delay …

Adipose tissue expresses cytokines that inhibit insulin signalling pathways in liver and
muscle. Obesity also results in impairment of endothelium-dependent vasodilatation in …

Insulin increases glucose disposal into muscle. In addition, in vivo insulin elicits distinct nitric
oxide synthase-dependent vascular responses to increase total skeletal muscle blood flow …

Evidence suggests that insulin delivery to skeletal muscle interstitium is the rate-limiting step
in insulin-stimulated muscle glucose uptake and that this process is impaired by insulin …

The vascular system controls the delivery of nutrients and hormones to muscle, and a
number of hormones may act to regulate muscle metabolism and contractile performance by …

We examined the effects of inhibiting nitric oxide synthase with N ω-nitro-l-arginine-methyl
ester (l-NAME) on total hindlimb blood flow, muscle microvascular recruitment, and hindlimb …