The emerging role and targetability of the TCA cycle in cancer metabolism
NM Anderson, P Mucka, JG Kern, H Feng - Protein & cell, 2018 - academic.oup.com
The tricarboxylic acid (TCA) cycle is a central route for oxidative phosphorylation in cells,
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …
and fulfills their bioenergetic, biosynthetic, and redox balance requirements. Despite early …
Anaplastic thyroid carcinoma: from clinicopathology to genetics and advanced therapies
E Molinaro, C Romei, A Biagini, E Sabini… - Nature Reviews …, 2017 - nature.com
Anaplastic thyroid carcinoma (ATC) is a rare malignancy, accounting for 1–2% of all thyroid
cancers. Although rare, ATC accounts for the majority of deaths from thyroid carcinoma. ATC …
cancers. Although rare, ATC accounts for the majority of deaths from thyroid carcinoma. ATC …
Molecular pathogenesis and mechanisms of thyroid cancer
M Xing - Nature Reviews Cancer, 2013 - nature.com
Thyroid cancer is a common endocrine malignancy. There has been exciting progress in
understanding its molecular pathogenesis in recent years, as best exemplified by the …
understanding its molecular pathogenesis in recent years, as best exemplified by the …
Inhibition of α-KG-dependent histone and DNA demethylases by fumarate and succinate that are accumulated in mutations of FH and SDH tumor suppressors
Two Krebs cycle genes, fumarate hydratase (FH) and succinate dehydrogenase (SDH), are
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
mutated in a subset of human cancers, leading to accumulation of their substrates, fumarate …
Marked for death: targeting epigenetic changes in cancer
SX Pfister, A Ashworth - Nature reviews Drug discovery, 2017 - nature.com
In the past few years, it has become clear that mutations in epigenetic regulatory genes are
common in human cancers. Therapeutic strategies are now being developed to target …
common in human cancers. Therapeutic strategies are now being developed to target …
Cancer development, progression, and therapy: an epigenetic overview
S Sarkar, G Horn, K Moulton, A Oza, S Byler… - International journal of …, 2013 - mdpi.com
Carcinogenesis involves uncontrolled cell growth, which follows the activation of oncogenes
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …
and/or the deactivation of tumor suppression genes. Metastasis requires down-regulation of …
IDH1 and IDH2 Mutations in Tumorigenesis: Mechanistic Insights and Clinical Perspectives
Genes encoding for isocitrate dehydrogenases 1 and 2, IDH1 and IDH2, are frequently
mutated in multiple types of human cancer. Mutations targeting IDH1 and IDH2 result in …
mutated in multiple types of human cancer. Mutations targeting IDH1 and IDH2 result in …
Tumor development is associated with decrease of TET gene expression and 5-methylcytosine hydroxylation
The TET (ten–eleven translocation) family of α-ketoglutarate (α-KG)-dependent
dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to 5 …
dioxygenases catalyzes the sequential oxidation of 5-methylcytosine (5mC) to 5 …
Somatic mosaic IDH1 and IDH2 mutations are associated with enchondroma and spindle cell hemangioma in Ollier disease and Maffucci syndrome
TC Pansuriya, R van Eijk, P d'Adamo… - Nature …, 2011 - nature.com
Ollier disease and Maffucci syndrome are non-hereditary skeletal disorders characterized by
multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci …
multiple enchondromas (Ollier disease) combined with spindle cell hemangiomas (Maffucci …
TET proteins and the control of cytosine demethylation in cancer
L Scourzic, E Mouly, OA Bernard - Genome medicine, 2015 - Springer
The discovery that ten-eleven translocation (TET) proteins are α-ketoglutarate-dependent
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …
dioxygenases involved in the conversion of 5-methylcytosines (5-mC) to 5 …