Evolution of the knowledge of free radicals and other oxidants

S Di Meo, P Venditti - Oxidative medicine and cellular longevity, 2020 - Wiley Online Library
Free radicals are chemical species (atoms, molecules, or ions) containing one or more
unpaired electrons in their external orbitals and generally display a remarkable reactivity …

Reactive oxygen species in plant signaling

C Waszczak, M Carmody… - Annual review of plant …, 2018 - annualreviews.org
As fixed organisms, plants are especially affected by changes in their environment and have
consequently evolved extensive mechanisms for acclimation and adaptation. Initially …

[HTML][HTML] Innate-adaptive immunity interplay and redox regulation in immune response

L Sun, X Wang, J Saredy, Z Yuan, X Yang, H Wang - Redox biology, 2020 - Elsevier
Innate and adaptive immune cell activation and infiltration is the key characteristic of tissue
inflammation. The innate immune system is the front line of host defense in which innate …

Redox signaling by reactive electrophiles and oxidants

S Parvez, MJC Long, JR Poganik, Y Aye - Chemical reviews, 2018 - ACS Publications
The concept of cell signaling in the context of nonenzyme-assisted protein modifications by
reactive electrophilic and oxidative species, broadly known as redox signaling, is a uniquely …

Peroxiredoxins: guardians against oxidative stress and modulators of peroxide signaling

A Perkins, KJ Nelson, D Parsonage, LB Poole… - Trends in biochemical …, 2015 - cell.com
Peroxiredoxins (Prxs) are a ubiquitous family of cysteine-dependent peroxidase enzymes
that play dominant roles in regulating peroxide levels within cells. These enzymes, often …

[HTML][HTML] Hydrogen peroxide sensing, signaling and regulation of transcription factors

HS Marinho, C Real, L Cyrne, H Soares, F Antunes - Redox biology, 2014 - Elsevier
The regulatory mechanisms by which hydrogen peroxide (H 2 O 2) modulates the activity of
transcription factors in bacteria (OxyR and PerR), lower eukaryotes (Yap1, Maf1, Hsf1 and …

[HTML][HTML] European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

J Egea, I Fabregat, YM Frapart, P Ghezzi, A Görlach… - Redox biology, 2017 - Elsevier
Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Chemistry and biology of reactive oxygen species in signaling or stress responses

BC Dickinson, CJ Chang - Nature chemical biology, 2011 - nature.com
Reactive oxygen species (ROS) are a family of molecules that are continuously generated,
transformed and consumed in all living organisms as a consequence of aerobic life. The …

Fundamentals of redox regulation in biology

H Sies, RJ Mailloux, U Jakob - Nature Reviews Molecular Cell Biology, 2024 - nature.com
Oxidation–reduction (redox) reactions are central to the existence of life. Reactive species of
oxygen, nitrogen and sulfur mediate redox control of a wide range of essential cellular …

Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy

SC Gupta, D Hevia, S Patchva, B Park… - Antioxidants & redox …, 2012 - liebertpub.com
Significance: Extensive research during the last quarter century has revealed that reactive
oxygen species (ROS) produced in the body, primarily by the mitochondria, play a major role …