Acylcarnitines are fatty acid metabolites that play important roles in many cellular energy
metabolism pathways. They have historically been used as important diagnostic markers for …

Triglyceride molecules represent the major form of storage and transport of fatty acids within
cells and in the plasma. The liver is the central organ for fatty acid metabolism. Fatty acids …

Background Non-alcoholic fatty liver disease (NAFLD) is defined by the abundance of lipid
droplets (LDs) in hepatocytes. While historically considered simply a depot for energy …

The liver is an essential metabolic organ, and its metabolic activity is tightly controlled by
insulin and other metabolic hormones. Glucose is metabolized into pyruvate through …

Non-alcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation in
the absence of excess alcohol intake. NAFLD is the most common chronic liver disease, and …

The significance of fatty acid metabolism in cancer initiation and development is increasingly
accepted by scientists and the public due to the high prevalence of overweight and obese …

Long-chain fatty acyl-coenzyme As (CoAs) are critical regulatory molecules and metabolic
intermediates. The initial step in their synthesis is the activation of fatty acids by one of 13 …

Aims: Impaired fatty acid oxidation (FAO) in mitochondria of hepatocytes causes lipid
accumulation and excessive production of reactive oxygen species (ROS) and oxidative …

The peroxisome proliferator-activated receptor α (PPARα, or NR1C1) is a nuclear hormone
receptor activated by a structurally diverse array of synthetic chemicals known as …

Long-chain acyl-CoA synthetase-1 (ACSL1) contributes 80% of total ACSL activity in
adipose tissue and was believed to be essential for the synthesis of triacylglycerol. We …