[HTML][HTML] iPSC-based disease modeling and drug discovery in cardinal neurodegenerative disorders
H Okano, S Morimoto - Cell Stem Cell, 2022 - cell.com
It has been 15 years since the birth of human induced pluripotent stem cell (iPSC)
technology in 2007, and the scope of its application has been expanding. In addition to the …
technology in 2007, and the scope of its application has been expanding. In addition to the …
[HTML][HTML] Making neurons, made easy: The use of Neurogenin-2 in neuronal differentiation
Directed neuronal differentiation of human pluripotent stem cells (hPSCs), neural
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
progenitors, or fibroblasts using transcription factors has allowed for the rapid and highly …
Recent progress in translational engineered in vitro models of the central nervous system
The complexity of the human brain poses a substantial challenge for the development of
models of the CNS. Current animal models lack many essential human characteristics (in …
models of the CNS. Current animal models lack many essential human characteristics (in …
Understanding axial progenitor biology in vivo and in vitro
FJ Wymeersch, V Wilson, A Tsakiridis - Development, 2021 - journals.biologists.com
The generation of the components that make up the embryonic body axis, such as the spinal
cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction …
cord and vertebral column, takes place in an anterior-to-posterior (head-to-tail) direction …
Variants in saposin D domain of prosaposin gene linked to Parkinson's disease
Y Oji, T Hatano, SI Ueno, M Funayama, K Ishikawa… - Brain, 2020 - academic.oup.com
Recently, the genetic variability in lysosomal storage disorders has been implicated in the
pathogenesis of Parkinson's disease. Here, we found that variants in prosaposin (PSAP), a …
pathogenesis of Parkinson's disease. Here, we found that variants in prosaposin (PSAP), a …
Nanotopography promoted neuronal differentiation of human induced pluripotent stem cells
Inefficient neural differentiation of human induced pluripotent stem cells (hiPSCs) motivates
recent investigation of the influence of biophysical characteristics of cellular …
recent investigation of the influence of biophysical characteristics of cellular …
Cell therapy for spinal cord injury by using human iPSC-derived region-specific neural progenitor cells
K Kajikawa, K Imaizumi, M Shinozaki, S Shibata… - Molecular brain, 2020 - Springer
The transplantation of neural progenitor cells (NPCs) derived from human induced
pluripotent stem cells (iPSCs) has beneficial effects on spinal cord injury (SCI). However …
pluripotent stem cells (iPSCs) has beneficial effects on spinal cord injury (SCI). However …
Identifying therapeutic agents for amelioration of mitochondrial clearance disorder in neurons of familial Parkinson disease
A Yamaguchi, K Ishikawa, T Inoshita… - Stem Cell Reports, 2020 - cell.com
Parkinson disease (PD) is a neurodegenerative disorder caused by the progressive loss of
midbrain dopaminergic neurons, and mitochondrial dysfunction is involved in its …
midbrain dopaminergic neurons, and mitochondrial dysfunction is involved in its …
Single-cell transcriptomics reveals correct developmental dynamics and high-quality midbrain cell types by improved hESC differentiation
Stem cell technologies provide new opportunities for modeling cells in health and disease
and for regenerative medicine. In both cases, developmental knowledge and defining the …
and for regenerative medicine. In both cases, developmental knowledge and defining the …
[HTML][HTML] Astrocytes and microglia in neurodegenerative diseases: Lessons from human in vitro models
Both astrocytes and microglia fulfil homeostatic and immune functions in the healthy CNS.
Dysfunction of these cell types have been implicated in the pathomechanisms of several …
Dysfunction of these cell types have been implicated in the pathomechanisms of several …