The hypothalamus-pituitary-gonad axis: tales of mice and men

A Kaprara, IT Huhtaniemi - Metabolism, 2018 - Elsevier
Reproduction is controlled by the hypothalamic-pituitary-gonadal (HPG) axis. Gonadotropin-
releasing hormone (GnRH) neurons play a central role in this axis through production of …

Connecting metabolism and gonadal function: novel central neuropeptide pathways involved in the metabolic control of puberty and fertility

M Manfredi-Lozano, J Roa, M Tena-Sempere - Frontiers in …, 2018 - Elsevier
Albeit essential for perpetuation of species, reproduction is an energy-demanding function
that can be adjusted to body metabolic status. Reproductive maturation and function can be …

[HTML][HTML] Physiology of GNRH and gonadotropin secretion

P Marques, K Skorupskaite, KS Rozario… - Endotext …, 2022 - ncbi.nlm.nih.gov
Gonadotropin hormone-releasing hormone (GnRH) is the key regulator of the reproductive
axis. Its pulsatile secretion determines the pattern of secretion of the gonadotropins follicle …

The gentle art of saying NO: how nitric oxide gets things done in the hypothalamus

K Chachlaki, J Garthwaite, V Prevot - Nature Reviews Endocrinology, 2017 - nature.com
The chemical signalling molecule nitric oxide (NO), which freely diffuses through aqueous
and lipid environments, subserves an array of functions in the mammalian central nervous …

Neuroendocrine control of the menstrual cycle

JE Hall - Yen and Jaffe's reproductive endocrinology, 2019 - Elsevier
The pattern of regular ovulatory cycles required for normal reproduction in women is
achieved through precise functional and temporal integration of stimulatory and inhibitory …

Diet-induced hypothalamic inflammation, phoenixin, and subsequent precocious puberty

G Valsamakis, A Arapaki, D Balafoutas, E Charmandari… - Nutrients, 2021 - mdpi.com
Recent studies have shown a rise in precocious puberty, especially in girls. At the same
time, childhood obesity due to overnutrition and energy imbalance is rising too. Nutrition and …

Follicle size on day of trigger most likely to yield a mature oocyte

A Abbara, LN Vuong, VNA Ho, SA Clarke… - Frontiers in …, 2018 - frontiersin.org
Objective To identify follicle sizes on the day of trigger most likely to yield a mature oocyte
following hCG, GnRH agonist (GnRHa), or kisspeptin during IVF treatment. Design …

A second dose of kisspeptin-54 improves oocyte maturation in women at high risk of ovarian hyperstimulation syndrome: a Phase 2 randomized controlled trial

A Abbara, S Clarke, R Islam, JK Prague… - Human …, 2017 - academic.oup.com
STUDY QUESTION Can increasing the duration of LH-exposure with a second dose of
kisspeptin-54 improve oocyte maturation in women at high risk of ovarian hyperstimulation …

The differential roles for neurodevelopmental and neuroendocrine genes in shaping GnRH neuron physiology and deficiency

R Oleari, V Massa, A Cariboni, A Lettieri - International Journal of …, 2021 - mdpi.com
Gonadotropin releasing hormone (GnRH) neurons are hypothalamic neuroendocrine cells
that control sexual reproduction. During embryonic development, GnRH neurons migrate …

Kisspeptins, new local modulators of male reproduction: A comparative overview

R Meccariello, S Fasano, R Pierantoni - General and comparative …, 2020 - Elsevier
Spermatogenesis is a complex process that leads to the production of male gametes within
the testis through the coordination of mitotic, meiotic and differentiation events, under a deep …