[HTML][HTML] Foam cells in atherosclerosis: novel insights into its origins, consequences, and molecular mechanisms

Y Gui, H Zheng, RY Cao - Frontiers in Cardiovascular Medicine, 2022 - frontiersin.org
Foam cells play a vital role in the initiation and development of atherosclerosis. This review
aims to summarize the novel insights into the origins, consequences, and molecular …

[HTML][HTML] Antioxidants and atherosclerosis: mechanistic aspects

K Malekmohammad, RDE Sewell, M Rafieian-Kopaei - Biomolecules, 2019 - mdpi.com
Atherosclerosis is a chronic inflammatory disease which is a major cause of coronary heart
disease and stroke in humans. It is characterized by intimal plaques and cholesterol …

Comparative pathology of aging great apes: bonobos, chimpanzees, gorillas, and orangutans

LJ Lowenstine, R McManamon… - Veterinary …, 2016 - journals.sagepub.com
The great apes (chimpanzees, bonobos, gorillas, and orangutans) are our closest relatives.
Despite the many similarities, there are significant differences in aging among apes …

[HTML][HTML] Novel therapeutic targets for hypoxia-related cardiovascular diseases: the role of HIF-1

M Liu, G Galli, Y Wang, Q Fan, Z Wang, X Wang… - Frontiers in …, 2020 - frontiersin.org
Insufficient oxygen availability (hypoxia) is a precursor to numerous cardiovascular
diseases, including atherosclerosis, pulmonary hypertension, and heart failure. The main …

Poria cocos polysaccharides attenuated ox-LDL-induced inflammation and oxidative stress via ERK activated Nrf2/HO-1 signaling pathway and inhibited foam cell …

J Zhao, X Niu, J Yu, X Xiao, W Li, L Zang, Z Hu… - International …, 2020 - Elsevier
Oxidative stress, inflammation, and foam cell formation in vascular smooth muscle cells
(VSMCs) are considered to play crucial roles in the pathogenesis of atherosclerosis. Poria …

Pathogenesis of atherosclerosis

T Wang, J Butany - Diagnostic histopathology, 2017 - Elsevier
The pathogenesis of atherosclerosis involves a complex interplay of endothelial dysfunction,
lipid accumulation, inflammation, vascular smooth muscle cell proliferation, matrix turnover …

Nanomedicine approaches for advanced diagnosis and treatment of atherosclerosis and related ischemic diseases

B Hu, KO Boakye‐Yiadom, W Yu… - Advanced …, 2020 - Wiley Online Library
Cardiovascular diseases (CVDs) remain one of the major causes of mortality worldwide. In
response to this and other worldwide health epidemics, nanomedicine has emerged as a …

[HTML][HTML] Vasculoprotective effects of vildagliptin. Focus on atherogenesis

M Wiciński, K Górski, E Wódkiewicz, M Walczak… - International journal of …, 2020 - mdpi.com
Vildagliptin is a representative of Dipeptidyl Peptidase-4 (DPP-4) inhibitors,
antihyperglycemic drugs, approved for use as monotherapy and combination therapy in type …

Vascular‐targeted nanocarriers: design considerations and strategies for successful treatment of atherosclerosis and other vascular diseases

WJ Kelley, H Safari, G Lopez‐Cazares… - Wiley …, 2016 - Wiley Online Library
Vascular‐targeted nanocarriers are an attractive option for the treatment of a number of
cardiovascular diseases, as they allow for more specific delivery and increased efficacy of …

Pathophysiology of atherosclerosis

MA Seidman, RN Mitchell, JR Stone - Cellular and molecular pathobiology …, 2014 - Elsevier
Atherosclerosis is the pathologic process of lipid accumulation, scarring, and inflammation in
the vascular wall, particularly the subendothelial (intimal) space of arteries, leading to …