Multi-component reactions (MCRs) are considered to be an important methodological
arsenal in synthetic and medicinal chemistry. These reactions have been strategically …

Chiral indole derivatives such as indolines and indolenines are important heterocyclic
frameworks which constitute the core structures of many natural products and bioactive …

Beyond esoteric interest, organocatalysis has now become one major pillar of asymmetric
catalysis. Here, we discuss how new activation modes are conquering challenging …

The precise construction of chiral molecules is a core research area in chemical science and
technology. Among the plethora of reported synthetic methods, asymmetric catalysis has …

Multicomponent reactions (MCRs) are powerful synthetic tools in which more than two
starting materials couple with each other to form multi-functionalized compounds in a one …

The well‐defined conformational properties of axially chiral compounds bring extraordinary
values to an assortment of bioactive molecules, advanced materials, organocatalysts as well …

The synthesis of ultra-stable chiral porous organic cages (POCs) and their controllable chiral
self-sorting at the molecular and supramolecular level remains challening. Herein, we report …

The generation of multiple bonds in one reaction step has attracted massive interest in drug
discovery and development. Multicomponent reactions (MCRs) offer the advantage of …

An efficient organocatalytic atroposelective three‐component cascade reaction of 2, 3‐
diketoesters, aromatic amines, and 1, 3‐cyclohexanediones has been developed for the …

This perspective aims at celebrating the 100th anniversary of the discovery of the Passerini
three component reaction. After being nearly neglected for many years, now this reaction …