Surfactant proteins A (SP-A) and D (SP-D) are soluble innate immune molecules which
maintain lung homeostasis through their dual roles as anti-infectious and …

To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

Arguably targeting is one of the biggest problems for controlled drug delivery. In the case
that drugs can be directed with high efficiency to the target tissue, side effects of medication …

The collectins family encompasses several collagenous Ca 2+-dependent defense lectins
that are described as pathogen recognition molecules. They play an important role in both …

Abstract Surfactant protein D (SP-D) is critical for maintenance of lung homeostasis and
provides a first line of defense to pathogens at mucosal surfaces. Polymorphisms in the SP …

Defense collagens and other soluble pattern recognition receptors contain the ability to
recognize and bind molecular patterns associated with pathogens (PAMPs) or apoptotic …

Introduction 2.1. The collectins 2.2. Structural organisation of the collectins 2.3. The lung
collectins SP-A and SP-D 2.3. 1. Surfactant protein A 2.3. 2. Surfactant protein D 3. Ligands …

The coronavirus disease 2019 (COVID-19) pandemic has resulted in a substantial global
public healthcare crisis, leading to the urgent need for effective therapeutic strategies …

Surfactant proteins A and D (SP-A and-D) play a role in many acute bacterial, viral, and
fungal infections and in acute allergic responses. In vitro, human SPs bind Mycobacterium …

Soluble pattern-recognition innate immune proteins functionally resemble the antibodies of
the adaptive immune system. Two major families of such proteins are ficolins and collectins …