Wound healing is a complex, dynamic process supported by a myriad of cellular events that
must be tightly coordinated to efficiently repair damaged tissue. Derangement in wound …

As the first defensive line between the human body and the outside world, the skin is
vulnerable to damage from the external environment. Skin wounds can be divided into acute …

The extracellular matrix (ECM) is a dynamic structure that surrounds and anchors cellular
components in tissues. In addition to functioning as a structural scaffold for cellular …

BACKGROUND Keloid and hypertrophic scars represent an aberrant response to the wound
healing process. These scars are characterized by dysregulated growth with excessive …

Scar formation is a common consequence of skin injuries that lead to a wide range of
adverse effects including physical deformities and psychological disorders. Studies …

Elastin is the main component of elastic fibers, which provide stretch, recoil, and elasticity to
the skin. Normal levels of elastic fiber production, organization, and integration with other …

Dermal fibroblasts, which make up the major cell type in the dermis, have, historically, been
considered to be relatively 'passive'cells which are responsible for the synthesis and …

Collagen is a biopolymer found in the animal body. It is one of the most abundant proteins in
the extracellular matrix that provides strength to the skin, joints, and bones in the human …

Management of incisional scar is intimately connected to stages of wound healing. The
management of an elective surgery patient begins with a thorough informed consent …

Introduction The secretion of trophic factors by mesenchymal stromal cells has gained
increased interest given the benefits it may bring to the treatment of a variety of traumatic …