BACKGROUND The integrated stress response (ISR) is an evolutionarily conserved
intracellular signaling network that helps the cell, tissue, and organism to adapt to a variable …

Opioid drugs are potent modulators of many physiological and psychological processes.
When given acutely, they can elicit the signature responses of euphoria and analgesia that …

We recently reported that a conditioned stimulus (CS) memory retrieval-extinction procedure
decreases reinstatement of cocaine and heroin seeking in rats and heroin craving in …

The integrated stress response (ISR) is a highly conserved biochemical pathway that
regulates protein synthesis. The ISR is activated in response to diverse stressors to restore …

Since its rediscovery at the beginning of the 21st Century, memory reconsolidation has been
proposed to be a therapeutic target for reducing the impact of emotional memories that can …

More and more evidence shows how brain energy metabolism is the linkage between
physiological and morphological synaptic plasticity and memory consolidation. Different …

Mounting evidence from clinical, epidemiological, neuropathology and preclinical studies
indicates that mechanisms similar to those leading to peripheral metabolic deregulation in …

Persistent traces of drug reward memories contribute to intense craving and often trigger
relapse. A number of pharmacological interventions on drug-associated memories have …

Addiction is a chronic, relapsing disorder. The progression to pathological drug-seeking is
thought to be driven by maladaptive learning processes which store and maintain …

The persistence of drug memory contributes to relapse to drug seeking. The association
between repeated drug exposure and drug-related cues leads to cravings triggered by drug …