Population pharmacokinetic modelling is widely used within the field of clinical
pharmacology as it helps to define the sources and correlates of pharmacokinetic variability …

The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …

Population pharmacokinetic (popPK) approaches have spread widely throughout clinical
pharmacology research, and every clinician should have some understanding of them. After …

This tutorial describes the development of a population pharmacokinetic (Pop PK) analysis
guidance within Pfizer, which strives for improved consistency and efficiency, and a more …

Meropenem dosing in critically ill patients with septic shock and continuous renal
replacement therapy (CRRT) is complex, with the recommended maintenance doses being …

The aim of the present study was to build a population pharmacokinetic (popPK) model to
characterize benznidazole (BNZ) pharmacokinetics in adults with chronic Chagas disease …

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Interleukin (IL)‐6 is a cytokine known
for pleiotropic and pro‐inflammatory functions. IL‐6 is involved in various disease processes …

The objective of this study was to characterize the pharmacokinetic/pharmacodynamic
(PK/PD) relationship of buprenorphine and fentanyl for the respiratory depressant effect in …

The objective of this investigation was to characterize the pharmacokinetic/
pharmacodynamic correlation of buprenorphine and fentanyl for the antinociceptive effect in …

Abstract Background and Objective Valproic acid (VPA) follows a non-linear
pharmacokinetic profile in terms of protein-binding saturation. The total daily dose regarding …