The 90-kDa molecular chaperone family (which comprises, among other proteins, the 90-
kDa heat-shock protein, hsp90 and the 94-kDa glucose-regulated protein, grp94, major …

At a first glance, ribosome biogenesis and chromatin remodeling are quite different
processes, but they share a common problem involving interactions between charged …

The mammalian cell nucleus contains numerous sub-compartments, which have been
implicated in essential processes such as transcription and splicing,. The mechanisms by …

The Third Edition of Chromatin: Structure and Function brings the reader up-to-date with the
remarkable progress in chromatin research over the past three years. It has been …

In response to decreased cellular oxygen concentrations the basic helix‐loop‐helix
(bHLH)/PAS (P er, A rnt, S im) hypoxia‐inducible transcription factor, HIF‐1α, mediates …

Abstract The recurrent translocation t (8; 16)(p11; p13) is a cytogenetic hallmark for the
M4/M5 subtype of acute myeloid leukaemia. Here we identify the breakpoint-associated …

Identification of the mechanisms by which the coagulation protease thrombin activates
platelets is critical for understanding haemostasis and thrombosis. Thrombin activates cells …

The existence and functioning of intrinsically disordered proteins (IDPs) challenge the
classical structure-function paradigm that equates function with a well-defined 3D structure …

The SR proteins constitute a large family of nuclear phosphoproteins required for
constitutive pre-mRNA splicing. These factors also have global, concentration-dependent …

We have purified a cytosolic protein from Xenopus eggs that is essential for selective protein
import into the cell nucleus. The purified protein, named importin, promotes signal …