Lysine acetylation is a widespread and versatile protein post-translational modification.
Lysine acetyltransferases and lysine deacetylases catalyse the addition or removal …

Epigenetic regulation of gene expression provides a finely tuned response capacity for cells
when undergoing environmental changes. However, in the context of human physiology or …

Radiation‐induced fibrosis (RIF) develops months to years after initial radiation exposure.
RIF occurs when normal fibroblasts differentiate into myofibroblasts and lay down aberrant …

Acetylation, a key component in post-translational modification regulated by HATs and
HDACs, is relevant to many crucial cellular contexts in organisms. Based on crucial …

Plumbagin (PLB) is an active secondary metabolite extracted from the roots of Plumbago
rosea. In this study, we report that plumbagin effectively induces paraptosis by triggering …

The reversible acetylation of lysines is one of the best characterized epigenetic
modifications. Its involvement in many key physiological and pathological processes has …

The 'language'of covalent histone modifications translates environmental and cellular cues
into gene expression. This vast array of post-translational modifications on histones are …

Acetylation of histone and non-histone protein lysine residues has been widely described as
a critical modulator of several cell functions in humans. Lysine acetyltransferases (KATs) …

Selective inhibitors of the two paralogue KAT3 acetyltransferases (CBP and p300) may
serve not only as precious chemical tools to investigate the role of these enzymes in …

Chromatin packaging of DNA provides a framework for transcriptional regulation.
Modifications to DNA and histone proteins in nucleosomes lead to conformational changes …