Protein arginine methyltransferases (PRMTs) are emerging as attractive therapeutic targets.
PRMTs regulate transcription, splicing, RNA biology, the DNA damage response and cell …

Protein methylation, a post-translational modification (PTM), is observed in a wide variety of
cell types from prokaryotes to eukaryotes. With recent and rapid advancements in epigenetic …

Arginine methylation is a common post-translational modification functioning as an
epigenetic regulator of transcription and playing key roles in pre-mRNA splicing, DNA …

The coactivator associated arginine methyltransferase (CARM1) promotes transcription, as
its name implies. It does so by modifying histones and chromatin bound proteins. We …

Chemotherapy represents an important treatment option for colorectal cancer (CRC), but
only half of the patients benefit from these regimens. We explored the potential predicting …

Arginine methylation is a ubiquitous post-translational modification. Three predominant
types of arginine-guanidino methylation occur in Eukarya: mono (Rme1/MMA), symmetric …

Abstract Histone lysine demethylase 1 (LSD 1), the first identified histone demethylase, is
overexpressed in multiple tumor types, including breast cancer. However, the mechanisms …

Protein arginine methyltransferases (PRMTs) introduce arginine methylation, a post-
translational modification with the increasingly eminent role in normal physiology and …

Protein arginine methylation is a common post-translational modification involved in
numerous cellular processes including transcription, DNA repair, mRNA splicing and signal …

Abstract Protein arginine methyltransferase (PRMT) 4 (also known as coactivator-associated
arginine methyltransferase 1; CARM1) is involved in a variety of biological processes and is …