Exploring free-energy landscapes of intrinsically disordered proteins at atomic resolution using NMR spectroscopy
The last 15 years have seen a paradigm shift in our understanding of protein biochemistry,
with the realization that an unexpectedly high fraction of the human genome codes for …
with the realization that an unexpectedly high fraction of the human genome codes for …
How random are intrinsically disordered proteins? A small angle scattering perspective
V Receveur-Bréchot, D Durand - Current Protein and Peptide …, 2012 - ingentaconnect.com
While the crucial role of intrinsically disordered proteins (IDPs) in the cell cycle is now
recognized, deciphering their molecular mode of action at the structural level still remains …
recognized, deciphering their molecular mode of action at the structural level still remains …
A short motif in the N-terminal region of α-synuclein is critical for both aggregation and function
CPA Doherty, SM Ulamec, R Maya-Martinez… - Nature structural & …, 2020 - nature.com
Aggregation of human α-synuclein (αSyn) is linked to Parkinson's disease (PD) pathology.
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …
The central region of the αSyn sequence contains the non-amyloid β-component (NAC) …
Single residue modulators of amyloid formation in the N-terminal P1-region of α-synuclein
SM Ulamec, R Maya-Martinez, EJ Byrd… - Nature …, 2022 - nature.com
Alpha-synuclein (αSyn) is a protein involved in neurodegenerative disorders including
Parkinson's disease. Amyloid formation of αSyn can be modulated by the 'P1 …
Parkinson's disease. Amyloid formation of αSyn can be modulated by the 'P1 …
C-terminal truncation modulates α-Synuclein's cytotoxicity and aggregation by promoting the interactions with membrane and chaperone
C Zhang, Y Pei, Z Zhang, L Xu, X Liu, L Jiang… - Communications …, 2022 - nature.com
Abstract α-Synuclein (α-syn) is the main protein component of Lewy bodies, the major
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …
pathological hallmarks of Parkinson's disease (PD). C-terminally truncated α-syn is found in …
Dynamic protein interaction networks and new structural paradigms in signaling
Understanding signaling and other complex biological processes requires elucidating the
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …
critical roles of intrinsically disordered proteins (IDPs) and regions (IDRs), which represent∼ …
NMR characterization of long-range order in intrinsically disordered proteins
Intrinsically disordered proteins (IDPs) are predicted to represent a significant fraction of the
human genome, and the development of meaningful molecular descriptions of these …
human genome, and the development of meaningful molecular descriptions of these …
α-Synuclein in Parkinson's disease: causal or bystander?
Parkinson's disease (PD) comprises a spectrum of disorders with differing subtypes, the vast
majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …
majority of which share Lewy bodies (LB) as a characteristic pathological hallmark. The …
Predictive atomic resolution descriptions of intrinsically disordered hTau40 and α-synuclein in solution from NMR and small angle scattering
The development of molecular descriptions of intrinsically disordered proteins (IDPs) is
essential for elucidating conformational transitions that characterize common …
essential for elucidating conformational transitions that characterize common …
alpha-Synuclein posttranslational modification and alternative splicing as a trigger for neurodegeneration
K Beyer, A Ariza - Molecular neurobiology, 2013 - Springer
Lewy body diseases include Parkinson disease and dementia with Lewy bodies and are
characterized by the widespread distribution of Lewy bodies in virtually every brain area …
characterized by the widespread distribution of Lewy bodies in virtually every brain area …