The role of the immune system in posttraumatic stress disorder

S Katrinli, NCS Oliveira, JC Felger… - Translational …, 2022 - nature.com
Posttraumatic stress disorder (PTSD) develops in a subset of individuals upon exposure to
traumatic stress. In addition to well-defined psychological and behavioral symptoms, some …

The impact of acute and chronic stress on gastrointestinal physiology and function: a microbiota–gut–brain axis perspective

SJ Leigh, F Uhlig, L Wilmes… - The Journal of …, 2023 - Wiley Online Library
The physiological consequences of stress often manifest in the gastrointestinal tract.
Traumatic or chronic stress is associated with widespread maladaptive changes throughout …

Early life adversity as a risk factor for cognitive impairment and Alzheimer's disease

Z Huang, JD Jordan, Q Zhang - Translational neurodegeneration, 2023 - Springer
Neurological conditions, including cognitive impairment and Alzheimer's disease (AD),
impose a huge burden on society, affecting millions of people globally. In addition to genetic …

Obesity is associated with a distinct brain-gut microbiome signature that connects Prevotella and Bacteroides to the brain's reward center

TS Dong, M Guan, EA Mayer, J Stains, C Liu, P Vora… - Gut …, 2022 - Taylor & Francis
The prevalence of obesity has risen to its highest values over the last two decades. While
many studies have either shown brain or microbiome connections to obesity, few have …

Stress gets into the belly: Early life stress and the gut microbiome

L Hantsoo, BS Zemel - Behavioural brain research, 2021 - Elsevier
Research has established that stress “gets under the skin,” impacting neuroendocrine and
neuroimmune pathways to influence risk for physical and mental health outcomes. These …

Gut microbiota metabolites mediate the interplay between childhood maltreatment and psychopathology in patients with eating disorders

G Castellini, E Cassioli, F Vitali, E Rossi, C Dani… - Scientific Reports, 2023 - nature.com
Eating disorders (EDs) are syndromes with a multifactorial etiopathogenesis, involving
childhood traumatic experiences, as well as biological factors. Human microbiome has been …

The gut microbiome in early life stress: a systematic review

A Agusti, F Lamers, M Tamayo, C Benito-Amat… - Nutrients, 2023 - mdpi.com
Exposure to early life stress (ELS), prenatal or postnatal during childhood and adolescence,
can significantly impact mental and physical health. The role of the intestinal microbiome in …

Advances in stress and depression research

J LeMoult, AM Battaglini, B Grocott… - Current Opinion in …, 2023 - journals.lww.com
Recent studies highlight the importance of adopting a nuanced understanding of
mechanisms and moderators that explain the stress–depression link. We also encourage …

[HTML][HTML] How discrimination gets under the skin: biological determinants of discrimination associated with dysregulation of the brain-gut microbiome system and …

TS Dong, GC Gee, H Beltran-Sanchez, M Wang… - Biological …, 2023 - Elsevier
Background Discrimination is associated with negative health outcomes as mediated in part
by chronic stress, but a full understanding of the biological pathways is lacking. Here we …

Discrimination exposure impacts unhealthy processing of food cues: crosstalk between the brain and gut

X Zhang, H Wang, LA Kilpatrick, TS Dong… - Nature mental …, 2023 - nature.com
Experiences of discrimination are associated with adverse health outcomes, including
obesity. However, the mechanisms by which discrimination leads to obesity remain unclear …