[HTML][HTML] Lipid nanoparticles for mRNA delivery
Messenger RNA (mRNA) has emerged as a new category of therapeutic agent to prevent
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
and treat various diseases. To function in vivo, mRNA requires safe, effective and stable …
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
RNA therapeutics show a significant breakthrough for the treatment of otherwise incurable
diseases and genetic disorders by regulating disease-related gene expression. The …
diseases and genetic disorders by regulating disease-related gene expression. The …
Ionizable lipid nanoparticles for in utero mRNA delivery
RS Riley, MV Kashyap, MM Billingsley, B White… - Science …, 2021 - science.org
Clinical advances enable the prenatal diagnosis of genetic diseases that are candidates for
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …
gene and enzyme therapies such as messenger RNA (mRNA)–mediated protein …
Inhaled mRNA therapy for treatment of cystic fibrosis: Interim results of a randomized, double‐blind, placebo‐controlled phase 1/2 clinical study
SM Rowe, JB Zuckerman, D Dorgan, J Lascano… - Journal of Cystic …, 2023 - Elsevier
Background MRT5005, a codon-optimized CFTR mRNA, delivered by aerosol in lipid
nanoparticles, was designed as a genotype-agnostic treatment for CF lung disease …
nanoparticles, was designed as a genotype-agnostic treatment for CF lung disease …
[HTML][HTML] Non-immunotherapy application of LNP-mRNA: Maximizing efficacy and safety
I Vlatkovic - Biomedicines, 2021 - mdpi.com
Lipid nanoparticle (LNP) formulated messenger RNA-based (LNP-mRNA) vaccines came
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …
into the spotlight as the first vaccines against SARS-CoV-2 virus to be applied worldwide …
A Potent Branched-Tail Lipid Nanoparticle Enables Multiplexed mRNA Delivery and Gene Editing In Vivo
The clinical translation of messengerRNA (mRNA) drugs has been slowed by a shortage of
delivery vehicles that potently and safely shuttle mRNA into target cells. Here, we describe …
delivery vehicles that potently and safely shuttle mRNA into target cells. Here, we describe …
Amniotic fluid stabilized lipid nanoparticles for in utero intra-amniotic mRNA delivery
Congenital disorders resulting in pathological protein deficiencies are most often treated
postnatally with protein or enzyme replacement therapies. However, treatment of these …
postnatally with protein or enzyme replacement therapies. However, treatment of these …
Nanomaterials for mRNA‐based therapeutics: Challenges and opportunities
D Li, Q Liu, M Yang, H Xu, M Zhu… - Bioengineering & …, 2023 - Wiley Online Library
Messenger RNA (mRNA) holds great potential in developing immunotherapy, protein
replacement, and genome editing. In general, mRNA does not have the risk of being …
replacement, and genome editing. In general, mRNA does not have the risk of being …
[HTML][HTML] mRNA as novel technology for passive immunotherapy
T Schlake, A Thess, M Thran, I Jordan - Cellular and Molecular Life …, 2019 - Springer
While active immunization elicits a lasting immune response by the body, passive
immunotherapy transiently equips the body with exogenously generated immunological …
immunotherapy transiently equips the body with exogenously generated immunological …
Cellular Trafficking of Nanotechnology‐Mediated mRNA Delivery
P Huang, H Deng, C Wang, Y Zhou… - Advanced …, 2024 - Wiley Online Library
Messenger RNA (mRNA)‐based therapy has emerged as a powerful, safe, and rapidly
scalable therapeutic approach that involves technologies for both mRNA itself and the …
scalable therapeutic approach that involves technologies for both mRNA itself and the …