Methodology toward the stereoselective 1, 2-cis glycoside linkage using intramolecular
aglycon delivery (IAD) has been extensively developed. In the last two decades, progress …

Asparagine (N)-linked glycosylation is one of the most common co-and post-translational
modifications of both intra-and extracellularly distributing proteins, which directly affects their …

Human antibody 2G12 neutralizes a broad range of HIV-1 isolates. Hence, molecular
characterization of its epitope, which corresponds to a conserved cluster of oligomannoses …

We have discovered an unusual α-galactosylation using phenylthioglycoside of 4, 6-O-di-tert-
butylsilylene (DTBS)-protected galactose derivatives as a glycosyl donor, which was not …

Understanding the structure–function relationship of carbohydrates in biological systems is a
major challenge. Such investigations require fast and reliable access to structurally-defined …

The design of immunogens capable of eliciting broadly neutralizing antibodies is a major,
but elusive, goal of HIV vaccine research.[1] However, a small panel of broadly neutralizing …

Being recognized as an important constituent of the glycoprotein folding cycle, uridine
diphosphate-glucose: glycoprotein glucosyltransferase (UGGT) has been a subject of …

There are strong grounds to suppose that some selected glycosylation patterns of the HIV
viral protein gp120 can themselves serve as epitopes for potent, broadly neutralizing …

The folding of glycoproteins is primarily mediated by a quality control system in the ER, in
which UDP-Glc: glycoprotein glucosyltransferase (UGGT) serves as a “folding sensor”. In …

The fundamental role of glycoconjugates in many biological processes is now well
appreciated and has intensified the development of innovative and improved synthetic …