Wnt/β-catenin signaling has been broadly implicated in human cancers and experimental
cancer models of animals. Aberrant activation of Wnt/β-catenin signaling is tightly linked with …

Glioblastoma (GB) is the most frequent and aggressive primary tumor of the central nervous
system. Prognosis remains poor despite ongoing progress. In cases where the gadolinium …

Immunotherapy has had a tremendous impact on cancer treatment in the past decade, with
hitherto unseen responses at advanced and metastatic stages of the disease. However, the …

Lithium salts have been in the therapeutic toolbox for better or worse since the 19th century,
with purported benefit in gout, hangover, insomnia, and early suggestions that lithium …

Extracellular vesicles have emerged as important mediators of intercellular communication
in cancer, including by conveying tumor-promoting microRNAs between cells, but their …

The aryl hydrocarbon receptor (AHR) is highly expressed in multiple organs and tissues,
and there is increasing evidence that the AHR plays an important role in cellular …

Tumor cell invasion and resistance to therapy are the most intractable biological
characteristics of cancer and, therefore, the most challenging for current cancer research …

Reactive astrocytes are integral to the glioma microenvironment. Connexin43 (Cx43) is a
major gap junction protein in astrocytes and its expression is enhanced significantly in …

Indirubin is the crucial ingredient of Danggui Longhui Wan and Qing-Dai, traditional
Chinese medicine herbal formulas used for the therapy of chronic myelocytic leukemia in …

Glioblastoma (GB) is one of the deadliest brain cancers to afflict humans, and it has a very
poor survival rate even with treatment. The extracellular adenosine-generating enzyme …