Polymeric delivery of therapeutic nucleic acids
R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …
Entry of nanoparticles into cells: The importance of nanoparticle properties
J Zhao, MH Stenzel - Polymer Chemistry, 2018 - pubs.rsc.org
Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …
Living radical polymerization by the RAFT process–a third update
This paper provides a third update to the review of reversible deactivation radical
polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC (= S) SR) by a …
polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC (= S) SR) by a …
Cell-penetrating hyperbranched polyprodrug amphiphiles for synergistic reductive milieu-triggered drug release and enhanced magnetic resonance signals
The rational design of theranostic nanoparticles exhibiting synergistic turn-on of therapeutic
potency and enhanced diagnostic imaging in response to tumor milieu is critical for efficient …
potency and enhanced diagnostic imaging in response to tumor milieu is critical for efficient …
Increased RNAi Efficacy in Spodoptera exigua via the Formulation of dsRNA With Guanylated Polymers
O Christiaens, MG Tardajos, ZL Martinez Reyna… - Frontiers in …, 2018 - frontiersin.org
Lepidoptera comprise some of the most devastating herbivorous pest insects worldwide.
One of the most promising novel pest control strategies is exploiting the RNA interference …
One of the most promising novel pest control strategies is exploiting the RNA interference …
Red-emissive cell-penetrating polymer dots exhibiting thermally activated delayed fluorescence for cellular imaging
Fluorescence imaging in living cells is key to understanding many biological processes, yet
autofluorescence from the sample can lower sensitivity and hinder high-resolution imaging …
autofluorescence from the sample can lower sensitivity and hinder high-resolution imaging …
Cellular uptake of substrate-initiated cell-penetrating poly (disulfide) s
G Gasparini, EK Bang, G Molinard… - Journal of the …, 2014 - ACS Publications
Substrate-initiated, self-inactivating, cell-penetrating poly (disulfide) s (siCPDs) are
introduced as general transporters for the covalent delivery of unmodified substrates of free …
introduced as general transporters for the covalent delivery of unmodified substrates of free …
Substrate-initiated synthesis of cell-penetrating poly (disulfide) s
EK Bang, G Gasparini, G Molinard, A Roux… - Journal of the …, 2013 - ACS Publications
Lessons from surface-initiated polymerization are applied to grow cell-penetrating poly
(disulfide) s directly on substrates of free choice. Reductive depolymerization after cellular …
(disulfide) s directly on substrates of free choice. Reductive depolymerization after cellular …
Cell-penetrating, guanidinium-rich oligophosphoesters: effective and versatile molecular transporters for drug and probe delivery
CJ McKinlay, RM Waymouth… - Journal of the American …, 2016 - ACS Publications
The design, synthesis, and biological evaluation of a new family of highly effective cell-
penetrating molecular transporters, guanidinium-rich oligophosphoesters, are described …
penetrating molecular transporters, guanidinium-rich oligophosphoesters, are described …
Guanidinium-functionalized interpolyelectrolyte complexes enabling RNAi in resistant insect pests
KH Parsons, MH Mondal, CL McCormick… - …, 2018 - ACS Publications
RNAi-based technologies are ideal for pest control as they can provide species specificity
and spare nontarget organisms. However, in some pests biological barriers prevent use of …
and spare nontarget organisms. However, in some pests biological barriers prevent use of …