Polymeric delivery of therapeutic nucleic acids

R Kumar, CF Santa Chalarca, MR Bockman… - Chemical …, 2021 - ACS Publications
The advent of genome editing has transformed the therapeutic landscape for several
debilitating diseases, and the clinical outlook for gene therapeutics has never been more …

Entry of nanoparticles into cells: The importance of nanoparticle properties

J Zhao, MH Stenzel - Polymer Chemistry, 2018 - pubs.rsc.org
Knowledge of the interactions between nanoparticles (NPs) and cell membranes is of great
importance for the design of safe and efficient nanomedicines. Extensive studies aimed at …

Living radical polymerization by the RAFT process–a third update

G Moad, E Rizzardo, SH Thang - Australian Journal of Chemistry, 2012 - CSIRO Publishing
This paper provides a third update to the review of reversible deactivation radical
polymerization (RDRP) achieved with thiocarbonylthio compounds (ZC (= S) SR) by a …

Cell-penetrating hyperbranched polyprodrug amphiphiles for synergistic reductive milieu-triggered drug release and enhanced magnetic resonance signals

X Hu, G Liu, Y Li, X Wang, S Liu - Journal of the American …, 2015 - ACS Publications
The rational design of theranostic nanoparticles exhibiting synergistic turn-on of therapeutic
potency and enhanced diagnostic imaging in response to tumor milieu is critical for efficient …

Increased RNAi Efficacy in Spodoptera exigua via the Formulation of dsRNA With Guanylated Polymers

O Christiaens, MG Tardajos, ZL Martinez Reyna… - Frontiers in …, 2018 - frontiersin.org
Lepidoptera comprise some of the most devastating herbivorous pest insects worldwide.
One of the most promising novel pest control strategies is exploiting the RNA interference …

Red-emissive cell-penetrating polymer dots exhibiting thermally activated delayed fluorescence for cellular imaging

CJ Christopherson, NR Paisley, Z Xiao… - Journal of the …, 2021 - ACS Publications
Fluorescence imaging in living cells is key to understanding many biological processes, yet
autofluorescence from the sample can lower sensitivity and hinder high-resolution imaging …

Cellular uptake of substrate-initiated cell-penetrating poly (disulfide) s

G Gasparini, EK Bang, G Molinard… - Journal of the …, 2014 - ACS Publications
Substrate-initiated, self-inactivating, cell-penetrating poly (disulfide) s (siCPDs) are
introduced as general transporters for the covalent delivery of unmodified substrates of free …

Substrate-initiated synthesis of cell-penetrating poly (disulfide) s

EK Bang, G Gasparini, G Molinard, A Roux… - Journal of the …, 2013 - ACS Publications
Lessons from surface-initiated polymerization are applied to grow cell-penetrating poly
(disulfide) s directly on substrates of free choice. Reductive depolymerization after cellular …

Cell-penetrating, guanidinium-rich oligophosphoesters: effective and versatile molecular transporters for drug and probe delivery

CJ McKinlay, RM Waymouth… - Journal of the American …, 2016 - ACS Publications
The design, synthesis, and biological evaluation of a new family of highly effective cell-
penetrating molecular transporters, guanidinium-rich oligophosphoesters, are described …

Guanidinium-functionalized interpolyelectrolyte complexes enabling RNAi in resistant insect pests

KH Parsons, MH Mondal, CL McCormick… - …, 2018 - ACS Publications
RNAi-based technologies are ideal for pest control as they can provide species specificity
and spare nontarget organisms. However, in some pests biological barriers prevent use of …