The role of oxidative stress in NAFLD–NASH–HCC transition—focus on NADPH oxidases

D Gabbia, L Cannella, S De Martin - Biomedicines, 2021 - mdpi.com
A peculiar role for oxidative stress in non-alcoholic fatty liver disease (NAFLD) and its
transition to the inflammatory complication non-alcoholic steatohepatitis (NASH), as well as …

[HTML][HTML] Effects of environmental contaminants in water resources on nonalcoholic fatty liver disease

S Zheng, Y Yang, C Wen, W Liu, L Cao, X Feng… - Environment …, 2021 - Elsevier
The global prevalence of nonalcoholic fatty liver disease (NAFLD) has been increasing
rapidly in recent years, which is now estimated to be over 25%. NAFLD is one of the most …

Cyanobacterial Harmful Algal Bloom Toxin Microcystin and Increased Vibrio Occurrence as Climate-Change-Induced Biological Co-Stressors: Exposure and Disease …

S Chatterjee, M More - Toxins, 2023 - mdpi.com
The effects of global warming are not limited to rising global temperatures and have set in
motion a complex chain of events contributing to climate change. A consequence of global …

[HTML][HTML] Artificial intelligence-assisted digital pathology for non-alcoholic steatohepatitis: current status and future directions

V Ratziu, M Hompesch, M Petitjean… - Journal of …, 2024 - journal-of-hepatology.eu
The worldwide prevalence of non-alcoholic steatohepatitis (NASH) is increasing, causing a
significant medical burden, but no approved therapeutics are currently available. NASH drug …

Carbon tetrachloride (CCl4) accelerated development of non-alcoholic fatty liver disease (NAFLD)/steatohepatitis (NASH) in MS-NASH mice fed western diet …

G Zhang, X Wang, TY Chung, W Ye, L Hodge… - BMC …, 2020 - Springer
Background Multiple murine models of nonalcoholic fatty liver disease/steatohepatitis
(NAFLD/NASH) have been established by using obesogenic diets and/or chemical …

Cyanotoxin exposure and hepatocellular carcinoma

BY Hernandez, X Zhu, M Nagata, L Loo, O Chan… - Toxicology, 2023 - Elsevier
Cyanobacteria are ubiquitous in aquatic and terrestrial environments worldwide and include
a number of species producing tumor-promoting hepatotoxins. Human exposure to …

[HTML][HTML] Ursolic acid alleviates Kupffer cells pyroptosis in liver fibrosis by the NOX2/NLRP3 inflammasome signaling pathway

Y Wan, W Zhang, C Huang, J Jian, Y Zhang… - International …, 2022 - Elsevier
Pyroptosis has an important role in liver inflammation and fibrosis. The role of KC pyroptosis
in liver fibrosis was unclear. Ursolic acid (UA) has antifibrotic effects, but study on the effect …

Digital pathology and artificial intelligence in non-alcoholic steatohepatitis: current status and future directions

V Ratziu, M Hompesch, M Petitjean, C Serdjebi… - Journal of …, 2023 - Elsevier
Non-alcoholic steatohepatitis (NASH) prevalence is increasing worldwide, causing a
significant medical burden, but no approved therapeutics are currently available. NASH drug …

Oral cyanobacteria and hepatocellular carcinoma

BY Hernandez, X Zhu, HA Risch, L Lu, X Ma… - … Biomarkers & Prevention, 2022 - AACR
Background: Gut microbial alterations have been linked to chronic liver disease and
hepatocellular carcinoma (HCC). The role of the oral microbiome in liver cancer …

Nicotinamide adenine dinucleotide phosphate oxidases in glucose homeostasis and diabetes-related endothelial cell dysfunction

OI Brown, KI Bridge, MT Kearney - Cells, 2021 - mdpi.com
Oxidative stress within the vascular endothelium, due to excess generation of reactive
oxygen species (ROS), is thought to be fundamental to the initiation and progression of the …