Antigenic variation as a strategy to evade the host adaptive immune response has evolved
in divergent pathogens. Antigenic variation involves restricted, and often mutually exclusive …

Background Protists of the family Trypanosomatidae (phylum Euglenozoa) have gained
notoriety as parasites affecting humans, domestic animals, and agricultural plants. However …

Telomere maintenance is essential for genome integrity and chromosome stability in
eukaryotic cells harboring linear chromosomes, as telomere forms a specialized structure to …

Aneuploidy is widely observed in both unicellular and multicellular eukaryotes, usually
associated with adaptation to stress conditions. Chromosomal duplication stability is a …

Parasitic diseases caused by kinetoplastid parasites are a burden to public health
throughout tropical and subtropical regions of the world. TriTrypDB (https://tritrypdb. org) is a …

Several persistent pathogens employ antigenic variation to continually evade mammalian
host adaptive immune responses. African trypanosomes use variant surface glycoproteins …

Nucleic acid interactome data, such as chromosome conformation capture data and RNA–
DNA interactome data, are currently analyzed via pipelines that must be rerun for each new …

Trypanosomatids are protozoan parasites that cause human and animal neglected
diseases. Despite global efforts, effective treatments are still much needed. Phenotypic …

Trypanosoma brucei is the causal agent of African Trypanosomiasis in humans and other
animals. It maintains a long‐term infection through an antigenic variation based population …

Background Aneuploidy is widely observed in both unicellular and multicellular eukaryotes,
usually associated with adaptation to stress conditions. Chromosomal duplication stability is …