Molecular mechanisms of two-component signal transduction

CP Zschiedrich, V Keidel, H Szurmant - Journal of molecular biology, 2016 - Elsevier
Two-component systems (TCS) comprising sensor histidine kinases and response regulator
proteins are among the most important players in bacterial and archaeal signal transduction …

Biological insights from structures of two-component proteins

R Gao, AM Stock - Annual review of microbiology, 2009 - annualreviews.org
Two-component signal transduction based on phosphotransfer from a histidine protein
kinase to a response regulator protein is a prevalent strategy for coupling environmental …

Stimulus perception in bacterial signal-transducing histidine kinases

T Mascher, JD Helmann, G Unden - Microbiology and molecular …, 2006 - Am Soc Microbiol
Two-component signal-transducing systems are ubiquitously distributed communication
interfaces in bacteria. They consist of a histidine kinase that senses a specific environmental …

Ligand-binding PAS domains in a genomic, cellular, and structural context

JT Henry, S Crosson - Annual review of microbiology, 2011 - annualreviews.org
Per-Arnt-Sim (PAS) domains occur in proteins from all kingdoms of life. In the bacterial
kingdom, PAS domains are commonly positioned at the amino terminus of signaling proteins …

[HTML][HTML] The use of polyoxometalates in protein crystallography–An attempt to widen a well-known bottleneck

A Bijelic, A Rompel - Coordination Chemistry Reviews, 2015 - Elsevier
Polyoxometalates (POMs) are discrete polynuclear metal-oxo anions with a fascinating
variety of structures and unique chemical and physical properties. Their application in …

Thermodynamics of protein–ligand interactions: history, presence, and future aspects

R Perozzo, G Folkers, L Scapozza - Journal of Receptors and …, 2004 - Taylor & Francis
The understanding of molecular recognition processes of small ligands and biological
macromolecules requires a complete characterization of the binding energetics and …

Methyl-accepting chemotaxis proteins: a core sensing element in prokaryotes and archaea

AIM Salah Ud-Din, A Roujeinikova - Cellular and Molecular Life Sciences, 2017 - Springer
Chemotaxis is the directed motility by means of which microbes sense chemical cues and
relocate towards more favorable environments. Methyl-accepting chemotaxis proteins …

Bacterial sensor kinases: diversity in the recognition of environmental signals

T Krell, J Lacal, A Busch… - Annual review of …, 2010 - annualreviews.org
Bacteria sense and respond to a wide range of physical and chemical signals. Central to
sensing and responding to these signals are two-component systems, which have a sensor …

Cache domains that are homologous to, but different from PAS domains comprise the largest superfamily of extracellular sensors in prokaryotes

AA Upadhyay, AD Fleetwood, O Adebali… - PLoS computational …, 2016 - journals.plos.org
Cellular receptors usually contain a designated sensory domain that recognizes the signal.
Per/Arnt/Sim (PAS) domains are ubiquitous sensors in thousands of species ranging from …

Sensor domains of two-component regulatory systems

J Cheung, WA Hendrickson - Current opinion in microbiology, 2010 - Elsevier
Two-component systems regulate crucial cellular processes in microorganisms, and each
comprises a homodimeric histidine kinase receptor and a cytoplasmic response regulator …