Context Polycystic ovary syndrome (PCOS) is common and diagnosis requires an elevated
testosterone. The clinical importance of adrenal 11-oxyandrogens in PCOS is unclear …

Efficient and accurate methods to estimate insulin sensitivity (SI) and β-cell function (BCF)
are of great importance for studying the pathogenesis and treatment effectiveness of type 2 …

Metabolic-associated fatty liver disease (MAFLD) has been identified as risk factor of
incident type 2 diabetes (T2D), but the underlying postprandial mechanisms remain unclear …

Type 2 diabetes mellitus is a complex and under-treated disorder closely intertwined with
obesity. Adolescents with severe obesity and type 2 diabetes have a more aggressive …

Objective Adolescents with polycystic ovary syndrome (PCOS) and obesity can have insulin
resistance, dysglycemia, and hepatic steatosis. Excess pancreatic fat may disturb insulin …

Objective Polycystic ovary syndrome (PCOS) is characterized by hyperandrogenism, insulin
resistance, and hepatic steatosis (HS). Because dietary essential amino acid (EAA) …

Under healthy conditions, the pancreas responds to a glucose challenge by releasing
insulin. Insulin suppresses lipolysis in adipose tissue, thereby decreasing plasma glycerol …

Objects Imigliptin is a novel dipeptidyl peptidase-4 inhibitor. In the present study, we aimed
to evaluate the effects of imigliptin and alogliptin on insulin resistance and beta-cell function …

The mathematical modelling of biological systems has historically followed one of two
approaches: comprehensive and minimal. In comprehensive models, the involved biological …

Trotz vergleichbar hoher Adipositasprävalenz im Kindesalter sind Manifestationen eines
Diabetes mellitus Typ 2 (T2D) bei Kindern und Jugendlichen in Deutschland seltener als in …