Developing new drugs is too expensive and time-consuming. Accurately predicting the
interaction between drugs and targets will likely change how the drug is discovered …

Solute carrier transporters (SLCs) are a class of important transmembrane proteins that are
involved in the transportation of diverse solute ions and small molecules into cells. There are …

The plasma membrane proteome is a rich resource of functionally important and
therapeutically relevant protein targets. Distinguished by high hydrophobicity, heavy …

Protein engineering through directed evolution and (semi) rational approaches is routinely
applied to optimize protein properties for a broad range of applications in industry and …

Today, machine learning methods are widely employed in drug discovery. However, the
chronic lack of data continues to hamper their further development, validation, and …

Non-alcoholic fatty liver disease (NAFLD) has been shown to influence breast cancer
progression, but the underlying mechanisms remain unclear. In this study, we investigated …

Peptides are promising drug development frameworks that have been hindered by intrinsic
undesired properties including hemolytic activity. We aim to get a better insight into the …

Angiotensin-converting enzyme 2 (ACE2) is a metalloprotease that cleaves angiotensin II, a
peptide substrate involved in the regulation of hypertension. Here, we identified a series of …

Identification of differentially expressed proteins in a proteomics workflow typically
encompasses five key steps: raw data quantification, expression matrix construction, matrix …

Native amine dehydrogenases offer sustainable access to chiral amines, so the search for
scaffolds capable of converting more diverse carbonyl compounds is required to reach the …