The oxytocin receptor: from intracellular signaling to behavior
B Jurek, ID Neumann - Physiological reviews, 2018 - journals.physiology.org
The many facets of the oxytocin (OXT) system of the brain and periphery elicited nearly
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
25,000 publications since 1930 (see, as listed in PubMed), which revealed central roles for …
Alternative polyadenylation of mRNA precursors
Alternative polyadenylation (APA) is an RNA-processing mechanism that generates distinct
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
3′ termini on mRNAs and other RNA polymerase II transcripts. It is widespread across all …
[HTML][HTML] Tau activation of microglial cGAS–IFN reduces MEF2C-mediated cognitive resilience
Pathological hallmarks of Alzheimer's disease (AD) precede clinical symptoms by years,
indicating a period of cognitive resilience before the onset of dementia. Here, we report that …
indicating a period of cognitive resilience before the onset of dementia. Here, we report that …
What are 3′ UTRs doing?
C Mayr - Cold Spring Harbor perspectives in biology, 2019 - cshperspectives.cshlp.org
SUMMARY 3′ untranslated regions (3′ UTRs) of messenger RNAs (mRNAs) are best
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
known to regulate mRNA-based processes, such as mRNA localization, mRNA stability, and …
[HTML][HTML] Signalling pathways in autism spectrum disorder: mechanisms and therapeutic implications
CC Jiang, LS Lin, S Long, XY Ke, K Fukunaga… - Signal transduction and …, 2022 - nature.com
Autism spectrum disorder (ASD) is a prevalent and complex neurodevelopmental disorder
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
which has strong genetic basis. Despite the rapidly rising incidence of autism, little is known …
A network-biology perspective of microRNA function and dysfunction in cancer
MicroRNAs (miRNAs) participate in most aspects of cellular differentiation and homeostasis,
and consequently have roles in many pathologies, including cancer. These small non …
and consequently have roles in many pathologies, including cancer. These small non …
Regulation by 3′-untranslated regions
C Mayr - Annual review of genetics, 2017 - annualreviews.org
3′-untranslated regions (3′-UTRs) are the noncoding parts of mRNAs. Compared to
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …
yeast, in humans, median 3′-UTR length has expanded approximately tenfold alongside …
[PDF][PDF] Alternative 3′ UTRs modify the localization, regulatory potential, stability, and plasticity of mRNAs in neuronal compartments
Neurons localize mRNAs near synapses where their translation can be regulated by
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …
synaptic demand and activity. Differences in the 3′ UTRs of mRNAs can change their …
[HTML][HTML] U1 snRNP regulates cancer cell migration and invasion in vitro
Stimulated cells and cancer cells have widespread shortening of mRNA 3'-untranslated
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …
regions (3'UTRs) and switches to shorter mRNA isoforms due to usage of more proximal …
Identifying gene expression programs of cell-type identity and cellular activity with single-cell RNA-Seq
Identifying gene expression programs underlying both cell-type identity and cellular
activities (eg life-cycle processes, responses to environmental cues) is crucial for …
activities (eg life-cycle processes, responses to environmental cues) is crucial for …