Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …

The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …

The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …

Hereditary cone disorders (CDs) are characterized by defects of the cone photoreceptors or
retinal pigment epithelium underlying the macula, and include achromatopsia (ACHM), cone …

Mammalian photoreceptors contain specialised connecting cilia that connect the inner (IS) to
the outer segments (OS). Dysfunction of the connecting cilia due to mutations in ciliary …

Ciliary receptors and their certain downstream signaling components undergo intraflagellar
transport (IFT) as BBSome cargoes to maintain their ciliary dynamics for sensing and …

Highlights•The cilium is a nexus for numerous signaling pathways.•Intraflagellar transport
(IFT) and BBSome complexes function in ciliary signaling.•The IFT machinery traffics …

The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos
between membranes. The cargo sorting mechanism between cilia and other compartments …

Epithelial cells lining the ducts and tubules of the kidney nephron and collecting duct have a
single non-motile cilium projecting from their surface into the lumen of the tubule. These …

Ciliopathies encompass a group of genetic disorders characterized by defects in the
formation, maintenance, or function of cilia. Retinitis pigmentosa (RP) is frequently one of the …