Open sesame: how transition fibers and the transition zone control ciliary composition
FR Garcia-Gonzalo, JF Reiter - Cold Spring Harbor …, 2017 - cshperspectives.cshlp.org
Cilia are plasma membrane protrusions that act as cellular propellers or antennae. To
perform these functions, cilia must maintain a composition distinct from those of the …
perform these functions, cilia must maintain a composition distinct from those of the …
Composition, organization and mechanisms of the transition zone, a gate for the cilium
The cilium evolved to provide the ancestral eukaryote with the ability to move and sense its
environment. Acquiring these functions required the compartmentalization of a dynein …
environment. Acquiring these functions required the compartmentalization of a dynein …
[HTML][HTML] Signal transduction in primary cilia–analyzing and manipulating GPCR and second messenger signaling
The primary cilium projects from the surface of most vertebrate cells, where it senses
extracellular signals to regulate diverse cellular processes during tissue development and …
extracellular signals to regulate diverse cellular processes during tissue development and …
Causes and consequences of inherited cone disorders
S Roosing, AAHJ Thiadens, CB Hoyng… - Progress in retinal and …, 2014 - Elsevier
Hereditary cone disorders (CDs) are characterized by defects of the cone photoreceptors or
retinal pigment epithelium underlying the macula, and include achromatopsia (ACHM), cone …
retinal pigment epithelium underlying the macula, and include achromatopsia (ACHM), cone …
[HTML][HTML] RPGR: Its role in photoreceptor physiology, human disease, and future therapies
RD Megaw, DC Soares, AF Wright - Experimental eye research, 2015 - Elsevier
Mammalian photoreceptors contain specialised connecting cilia that connect the inner (IS) to
the outer segments (OS). Dysfunction of the connecting cilia due to mutations in ciliary …
the outer segments (OS). Dysfunction of the connecting cilia due to mutations in ciliary …
[HTML][HTML] ARL3 mediates BBSome ciliary turnover by promoting its outward movement across the transition zone
YX Liu, WY Sun, B Xue, RK Zhang, WJ Li… - The Journal of Cell …, 2022 - ncbi.nlm.nih.gov
Ciliary receptors and their certain downstream signaling components undergo intraflagellar
transport (IFT) as BBSome cargoes to maintain their ciliary dynamics for sensing and …
transport (IFT) as BBSome cargoes to maintain their ciliary dynamics for sensing and …
The intraflagellar transport machinery in ciliary signaling
Highlights•The cilium is a nexus for numerous signaling pathways.•Intraflagellar transport
(IFT) and BBSome complexes function in ciliary signaling.•The IFT machinery traffics …
(IFT) and BBSome complexes function in ciliary signaling.•The IFT machinery traffics …
PDE6δ-mediated sorting of INPP5E into the cilium is determined by cargo-carrier affinity
EK Fansa, SK Kösling, E Zent, A Wittinghofer… - Nature …, 2016 - nature.com
The phosphodiesterase 6 delta subunit (PDE6δ) shuttles several farnesylated cargos
between membranes. The cargo sorting mechanism between cilia and other compartments …
between membranes. The cargo sorting mechanism between cilia and other compartments …
Cilia in cystic kidney and other diseases
Epithelial cells lining the ducts and tubules of the kidney nephron and collecting duct have a
single non-motile cilium projecting from their surface into the lumen of the tubule. These …
single non-motile cilium projecting from their surface into the lumen of the tubule. These …
The role of RPGR and its interacting proteins in ciliopathies
SR Patnaik, RK Raghupathy, X Zhang… - Journal of …, 2015 - Wiley Online Library
Ciliopathies encompass a group of genetic disorders characterized by defects in the
formation, maintenance, or function of cilia. Retinitis pigmentosa (RP) is frequently one of the …
formation, maintenance, or function of cilia. Retinitis pigmentosa (RP) is frequently one of the …