Hepatocellular carcinoma is among the most lethal and prevalent cancers in the human
population. Despite its significance, there is only an elemental understanding of the …

Viral infections can cause rampant disease in human beings, ranging from mild to acute, that
can often be fatal unless resolved. An acute viral infection is characterized by sudden or …

Persistent human papillomavirus (HPV) infection is the leading cause of cervical cancer.
Although the fundamental link between HPV infection and oncogenesis is established, the …

The non-structural 5A (NS5A) protein of hepatitis C virus (HCV) has been the subject of
intensive research over the last decade. It is generally accepted that NS5A is a pleiotropic …

In infected cells, hepatitis C virus (HCV) core protein is targeted to lipid droplets, which serve
as intracellular storage organelles. Using a tissue culture system to generate infectious …

Attachment of hepatitis C virus (HCV) core protein to lipid droplets (LDs) is linked to release
of infectious progeny from infected cells. Core progressively coats the entire LD surface from …

Hepatitis C virus (HCV) establishes a persistent infection, with up to 80% of infected
individuals proceeding to chronic hepatitis, which in many cases may result in liver cirrhosis …

The mechanisms involved in hepatitis C virus (HCV) RNA replication are unknown, and this
aspect of the virus life cycle is not understood. It is thought that virus-encoded nonstructural …

Studies of the hepatitis C virus (HCV) life cycle have been aided by development of in vitro
systems that enable replication of viral RNA and production of infectious virus. However, the …

Abstract Background Hepatitis C virus (HCV) is a major cause of chronic liver disease by
infecting over 170 million people worldwide. Recent studies have shown that microRNAs …