Gene editing technologies (GETs) could induce gene knockdown or gene knockout for
biomedical applications. The clinical success of gene silence by RNAi therapies pays …

Non-traumatic intracerebral hemorrhage (ICH) is the most common type of hemorrhagic
stroke, most often occurring between the ages of 45 and 60. Hypertension is most often the …

Background Maternal stress before, during and after pregnancy has profound effects on the
development and lifelong function of the infant's neurocognitive development. We …

Genetic and epigenetic modifications of genes involved in the key regulatory pathways play
a significant role in the pathophysiology and progression of multifactorial diseases. The …

Acute myeloid leukemia (AML) is a malignant hematological disorder in which aberrant
cytokine signaling and inflammation play a role in disease initiation and progression …

Poplar (Populus) is a well-established model system for tree genomics and molecular
breeding, and hybrid poplar is widely used in forest plantations. However, distinguishing its …

Recent human genetic studies have linked a variety of genetic variants in the CACNA1C
and CACNA1D genes to neuropsychiatric and neurodevelopmental disorders. This is not …

MDM4 is an important p53-negative regulator, consequently, it is involved in cell
proliferation, DNA repair, and apoptosis regulation. MDM4 overexpression and amplification …

Parkinson's disease (PD) is second most prevalent neurodegenerative disorder following
Alzheimer's disease. Parkinson's disease is hypothesized to be caused by a multifaceted …

Penile squamous cell carcinoma (SCC) is a rare and aggressive tumour mainly related to
lifestyle behaviour and human papillomavirus (HPV) infection. Environmentally induced loss …