Cancer immunotherapy aims to initiate or amplify immune responses that eliminate cancer
cells and create immune memory to prevent relapse. Immune checkpoint inhibitors (ICIs) …

Chimeric antigen receptor (CAR)-T cells form dynamic immunological synapses with their
cancer cell targets. After a CAR-antigen engagement, the CAR-T synapse forms, matures …

Mucin-domain glycoproteins are densely O-glycosylated and play critical roles in a host of
biological functions. In particular, the T cell immunoglobulin and mucin-domain containing …

The T cell receptor (TCR) is thought to be a mechanosensor, meaning that it transmits
mechanical force to its antigen and leverages the force to amplify the specificity and …

Antibodies can block immune receptor engagement or trigger the receptor machinery to
initiate signaling. We hypothesized that antibody agonists trigger signaling by sterically …

Major Histocompatibility Complex (MHC) I and II and the αβ T-cell antigen receptor (TCRαβ)
govern fundamental traits of adaptive immunity. They form a membrane-borne ligand …

The viscous glycocalyx of mammalian cells, composed of glucosaminoglycans, glycolipids,
and glycoproteins,“sugar coat” the outer plasma membrane. In this issue of Developmental …

Proteins on the surfaces of cells serve as physical connection points to bridge one cell with
another, enabling direct communication between cells and cohesive structure. As …

T cell activation is initiated by the recognition of specific antigenic peptides and
subsequently accomplished by complex signaling cascades. These aspects have been …

T cell receptor (TCR) binding to cognate antigen on the plasma membrane of an antigen-
presenting cell (APC) triggers the immune synapse (IS) formation. The IS constitutes a …