Pancreatic ductal adenocarcinoma (PDAC) is a leading cause of cancer-related mortality in
the Western world with limited therapeutic options and dismal long-term survival. The …

Pancreatic cancer is a deadly disease with high mortality due to difficulties in its early
diagnosis and metastasis. The tumor microenvironment induced by interactions between …

Cerebrovascular dysregulation is a hallmark of Alzheimer's disease (AD), but the changes
that occur in specific cell types have not been fully characterized. Here, we profile single …

Signal transducer and activator of transcription 3 (STAT3) is a cytoplasmic transcription
factor that regulates cell proliferation, differentiation, apoptosis, angiogenesis, inflammation …

Secretion of C–C chemokine ligand 2 (CCL2) by mammary tumours recruits CCR2-
expressing inflammatory monocytes to primary tumours and metastatic sites, and CCL2 …

The metastasis is a multistep process in which a small proportion of cancer cells are
detached from the colony to enter into blood cells for obtaining a new place for metastasis …

The development and progression of human cancers are continuously and dynamically
regulated by intrinsic and extrinsic factors. As a converging point of multiple oncogenic …

Pancreatic cancer is one of the most lethal malignancies worldwide. Although the standard
of care in pancreatic cancer has improved, prognoses for patients remain poor with a 5-year …

Metastasis is powered by disseminated cancer cells that re-create a full-fledged tumor in
unwelcoming tissues, away from the primary site. How cancer cells moving from a tumor into …

Signal transducers and activators of transcription (STATs) comprise a family of cytoplasmic
transcription factors that mediate intracellular signaling that is usually generated at cell …