OP-EHEA191011_online 2313..2340 Page 1 Low-density lipoproteins cause atherosclerotic
cardiovascular disease: pathophysiological, genetic, and therapeutic insights: a consensus …

There is now overwhelming experimental and clinical evidence that atherosclerosis is a
chronic inflammatory disease. Lessons from genome-wide association studies, advanced in …

Atherosclerosis is an inflammatory disease within the arterial wall that is responsible for
several important adverse vascular events, including coronary artery disease, myocardial …

The cardiovascular system is subject to hyperlipidaemic, inflammatory, and pro-oxidant
stressors. Over time, these factors drive prevalent chronic diseases, of which atherosclerosis …

Atherosclerosis is a chronic inflammatory disorder that is the underlying cause of most
cardiovascular disease. Both cells of the vessel wall and cells of the immune system …

Natural Abs, belonging to isotypes IgM, IgG3, and IgA, were discovered nearly half a century
ago. Despite knowledge about the role of the polyreactive natural IgM in pathogen …

At least 468 individual genes have been manipulated by molecular methods to study their
effects on the initiation, promotion, and progression of atherosclerosis. Most clinicians and …

The existence of IgM has been known for more than a century, but its importance in immunity
and autoimmunity continues to emerge. Studies of mice deficient in secreted IgM have …

Oxidation reactions are vital parts of metabolism and signal transduction. However, they also
produce reactive oxygen species, which damage lipids, proteins and DNA, generating …

Complement factor H (CFH) negatively regulates consumption of complement component 3
(C3), thereby restricting complement activation. Genetic variants in CFH predispose to …