Phosphate plays essential roles in many biological processes, and the serum phosphate
level is tightly controlled. Chronic hypophosphatemia causes impaired mineralization of the …

Abstract Purpose of Review The study aims to provide updated information on the genetic
factors associated with the diagnoses 'Diffuse Idiopathic Skeletal Hyperostosis'(DISH),' …

ABSTRACT X‐linked hypophosphatemia (XLH), a dominant disorder caused by pathogenic
variants in the PHEX gene, affects both sexes of all ages and results in elevated serum …

Lebanon has a high annual incidence of birth defects at 63 per 1000 live births, most of
which are due to genetic factors. The Catalogue for Transmission Genetics in Arabs (CTGA) …

Objectives Pharmacogenetic testing is projected to improve health outcomes and reduce the
cost of care by increasing therapeutic efficacy and minimizing drug toxicity. American Indian …

Blood values of calcium (Ca), inorganic phosphorus (IP), and alkaline phosphatase activity
(ALP) are valuable indicators for mineral status and bone mineralization. The mineral …

The SIBLINGs are a subfamily of the secreted calcium-binding phosphoproteins and
comprise five small integrin-binding ligand N-linked glycoproteins [dentin matrix protein-1 …

Unlike treatments for most rickets, the treatment using 1, 25-(OH) 2 vitamin D3 has little
efficacy on patients with hypophosphatemic rickets, a set of rare genetic diseases. Thus …

Autosomal recessive hypophosphatemic rickets type 1 (ARHR1) was reported to be caused
by homozygous mutation of dentin matrix protein 1 (DMP1). To date, very few cases have …

Background Consanguinity is an important risk factor for autosomal recessive (AR)
disorders. Extended genomic regions identical by descent (IBD) in the offspring of …