Synthetic proteins behind the plasma barrier: Molecular spies

G Mann, P Sadhu, A Brik - Accounts of Chemical Research, 2022 - ACS Publications
Conspectus There is a continuous demand to improve our understanding of fundamental
processes that underlie human health and disease. Therefore, novel strategies that can …

[HTML][HTML] The role and mechanism of SUMO modification in liver disease

M Li, J Zhang, Z Li, Z Xu, S Qian, LJ Tay… - Biomedicine & …, 2024 - Elsevier
Liver disease affects millions of people in the world, and China has the highest prevalence
of liver disease in the world. Small ubiquitin-related modifier (SUMO) modification is a highly …

SISPRO: Signature Identification for Spatial Proteomics

Y Zhou, Y Zhang, F Li, X Lian, Q Zhu, F Zhu… - Journal of molecular …, 2023 - Elsevier
Spatial proteomics aims for a global description of organelle-specific protein distribution and
dynamics, which is essential for understanding the molecular functions and cellular …

Polyubiquitination and SUMOylation Sites Regulate the Stability of ZO-2 Protein and the Sealing of Tight Junctions

M Cano-Cortina, L Alarcón, J Miranda, O Huber… - Cells, 2022 - mdpi.com
Tight junctions (TJs) regulate the transit of ions and molecules through the paracellular
pathway in epithelial cells. Zonula occludens 2 (ZO-2) is a cytoplasmic TJ protein. Here, we …

蛋白质的SUMO 化修饰及其在玉米中的研究进展.

赖瑞强, 陈铭, 薛晓明, 胡元强… - Guangdong …, 2023 - search.ebscohost.com
小泛素化修饰(Small ubiquitin-like modification, SUMOylation) 是一种重要的蛋白质翻译后
修饰, 参与植物多种生命活动. 在这个修饰过程中, SUMO 蛋白通过共价键与靶蛋白结合 …

Multiplexed Delivery of Synthetic (Un) Conjugatable Ubiquitin and SUMO2 Enables Simultaneous Monitoring of Their Localization and Function in Live Cells

G Mann, P Sadhu, A Brik - ChemBioChem, 2022 - Wiley Online Library
Ubiquitin (Ub) and its related small Ub like modifier (SUMO) are among the most influential
protein post‐translational modifications in eukaryotes. Unfortunately, visualizing these …

Regulation of the hyperpolarization-activated cyclic nucleotide gated ion channel 2, HCN2, by post-translational SUMOylation

L Forster - 2022 - scholarworks.gsu.edu
The hyperpolarization activated cyclic nucleotide gated ion channels (HCN) are encoded by
4 isoforms (HCN1-4). These are nonspecific cation channels which mediate the slow inward …