Increasing evidence indicates the involvement of B cells in the pathogenesis of multiple
sclerosis (MS), but their precise roles are unclear. In this Review, we provide an overview of …

The chronic inflammatory neuropathies (CINs) are rare, very disabling autoimmune
disorders that generally respond well to immune therapies such as intravenous …

Background IgG 4-related disease (IgG 4-RD) is a poorly understood, multiorgan, chronic
inflammatory disease characterized by tumefactive lesions, storiform fibrosis, obliterative …

Binding of the complement component C1q to the CH2 domain of antigen-bound
immunoglobulin gamma (IgG) activates the classical complement pathway and depends on …

B cells foster squamous cell carcinoma (SCC) development through deposition of
immunoglobulin-containing immune complexes in premalignant tissue and Fcγ receptor …

New so-called immune reconstitution therapies (IRTs) have the potential to induce long-term
or even permanent drug-free remission in people with multiple sclerosis (MS). These …

Objective: To determine whether rituximab 375 mg/m2 was efficacious in patients with
immunoglobulin M (IgM) anti-myelin–associated glycoprotein antibody demyelinating …

B cells have an ever-increasing role in the etiopathology of a number of autoimmune
neurological disorders, acting as antigen-presenting cells facilitating antibody production but …

The anti-CD20 antibody ocrelizumab, approved for treatment of multiple sclerosis, leads to
rapid elimination of B cells from the blood. The extent of B cell depletion and kinetics of their …

Background 'Encephalomyelitis disseminata'(multiple sclerosis) and myalgic
encephalomyelitis/chronic fatigue syndrome (ME/CFS) are both classified as diseases of the …