[HTML][HTML] Reciprocal regulation of mesenchymal stem cells and immune responses

Y Wang, J Fang, B Liu, C Shao, Y Shi - Cell stem cell, 2022 - cell.com
Mesenchymal stem/stromal cells (MSCs) exist in almost all tissues and participate in tissue
regeneration and homeostasis. In-vitro-expanded MSCs are employed as therapeutics for …

[HTML][HTML] Mesenchymal stromal cells: putative microenvironmental modulators become cell therapy

M Krampera, K Le Blanc - Cell stem cell, 2021 - cell.com
An exceptional safety profile has been shown in a large number of cell therapy clinical trials
that use mesenchymal stromal cells (MSCs). However, reliable potency assays are still …

Trends in mesenchymal stem cell clinical trials 2004-2018: Is efficacy optimal in a narrow dose range?

M Kabat, I Bobkov, S Kumar… - Stem cells translational …, 2020 - academic.oup.com
The number of clinical trials using mesenchymal stem cells (MSCs) has increased since
2008, but this trend slowed in the past several years and dropped precipitously in 2018 …

Immunomodulation by therapeutic mesenchymal stromal cells (MSC) is triggered through phagocytosis of MSC by monocytic cells

SFH de Witte, F Luk, JM Sierra Parraga, M Gargesha… - stem cells, 2018 - academic.oup.com
Mesenchymal stem or stromal cells (MSC) are under investigation as a potential
immunotherapy. MSC are usually administered via intravenous infusion, after which they are …

Pathogenesis and treatment of Sjogren's syndrome: review and update

Q Zhan, J Zhang, Y Lin, W Chen, X Fan… - Frontiers in …, 2023 - frontiersin.org
Sjogren's syndrome (SS) is a chronic autoimmune disease accompanied by multiple
lesions. The main manifestations include dryness of the mouth and eyes, along with …

Salivary gland function, development, and regeneration

AM Chibly, MH Aure, VN Patel… - Physiological …, 2022 - journals.physiology.org
Salivary glands produce and secrete saliva, which is essential for maintaining oral health
and overall health. Understanding both the unique structure and physiological function of …

[HTML][HTML] Current state of stem cell-based therapies: an overview

RM Aly - Stem cell investigation, 2020 - ncbi.nlm.nih.gov
Recent research reporting successful translation of stem cell therapies to patients have
enriched the hope that such regenerative strategies may one day become a treatment for a …

Mesenchymal stem/stromal cells for rheumatoid arthritis treatment: an update on clinical applications

M Lopez-Santalla, R Fernandez-Perez, MI Garin - Cells, 2020 - mdpi.com
Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease that affects the lining of
the synovial joints leading to stiffness, pain, inflammation, loss of mobility, and erosion of …

Advances in mesenchymal stem cell therapy for immune and inflammatory diseases: Use of cell-free products and human pluripotent stem cell-derived mesenchymal …

LT Wang, KJ Liu, HK Sytwu, ML Yen… - Stem cells translational …, 2021 - academic.oup.com
Mesenchymal stem cell therapy (MSCT) for immune and inflammatory diseases continues to
be popular based on progressive accumulation of preclinical mechanistic evidence. This …

Stem cell therapies for wound healing

N Kosaric, H Kiwanuka, GC Gurtner - Expert opinion on biological …, 2019 - Taylor & Francis
Introduction: Aberrant wound healing is a significant healthcare problem, posing a
substantial burden on patients, their families, and the healthcare system. Existing treatment …