Molecules with restricted rotation around a single bond or atropisomers are found in a wide
number of natural products and bioactive molecules as well as in chiral ligands for …

Chirality plays a crucial role in life-sustaining processes, and for this reason asymmetric
synthesis has been a central research theme in many research groups in the field of organic …

A highly efficient method to access axially chiral anilides through asymmetric allylic
alkylation reaction with achiral Morita–Baylis–Hillman carbonates by using a biscinchona …

A new class of 6′‐hydroxy cinchona alkaloids, with a non‐biaryl atropisomeric
functionalisation at position 5′ of the quinoline core can be prepared by an easy amination …

Substrates, bearing axial chirality, can cyclize intra-or inter-molecularly with concomitant
transfer of axial-to-central chirality to produce at least one stereocenter. In order to satisfy a …

In the presence of (R)-DTBM-SEGPHOS− Pd (OAc) 2 catalyst, N-arylation (aromatic
amination) of various o-tert-butylanilides with p-iodonitrobenzene proceeds with high …

The first stereoselective synthesis of epimeloscine has been accomplished in 13 total steps
with a longest linear sequence of 10 steps. The core of the synthesis takes only five steps …

In common with other hindered structures containing two aromatic rings linked by a short
tether, diarylamines may exhibit atropisomerism (chirality due to restricted rotation). Previous …

The first catalytic asymmetric synthesis of axially chiral anilides has been carried out under
palladium-catalyzed allylation reaction conditions with chiral phosphine ligands. Allylation of …

Biaryl atropisomeric compounds I such as BINOL and BINAP have been widely used as
chiral ligands in catalytic asymmetric reactions and optical resolution reagents (Figure 1). 1 …